PDF(Pubmed)
Abstract：
Emotions are prominent in theories and accounts of schizophrenia but are largely understudied compared to cognition. Utilizing the Research Domain Criteria (RDoC) Negative Valence Systems framework, we review the current knowledge of emotions in schizophrenia. Given the pivotal role of threat responses in theories of schizophrenia and the substantial evidence of altered threat responses, we focus on three components of Negative Valence Systems tied to threat responses: responses to acute threat, responses to potential threat, and sustained threat.
Individuals with schizophrenia show altered responses to neutral stimuli during acute threat, bed nucleus of the stria terminalis connectivity in response to potential threat, and threat responses associated with sustained threat. Our review concludes that Negative Valence Systems are altered in schizophrenia; however, the level and evidence of alterations vary across the types of threat responses. We suggest avenues for future research to further understand and intervene on threat responses in schizophrenia.
Individuals with schizophrenia show altered responses to neutral stimuli during acute threat, bed nucleus of the stria terminalis connectivity in response to potential threat, and threat responses associated with sustained threat. Our review concludes that Negative Valence Systems are altered in schizophrenia; however, the level and evidence of alterations vary across the types of threat responses. We suggest avenues for future research to further understand and intervene on threat responses in schizophrenia.
摘要：
目的：情绪在精神分裂症的理论和解释中是突出的，但与认知相比，大部分研究不足。利用研究领域标准(RDoC)负价系统框架，我们回顾了精神分裂症的情绪知识。鉴于威胁反应在精神分裂症理论中的关键作用以及威胁反应改变的大量证据，我们专注于与威胁响应相关的负价系统的三个组成部分：对急性威胁的响应，对潜在威胁的反应，持续的威胁。
结果：精神分裂症患者在急性威胁期间对中性刺激的反应发生改变，响应潜在威胁的终末纹连接的床核，以及与持续威胁相关的威胁响应。我们的评论得出结论，负效价系统在精神分裂症中改变；然而，更改的级别和证据因威胁响应的类型而异。我们提出了未来研究的途径，以进一步了解和干预精神分裂症的威胁反应。
结果：精神分裂症患者在急性威胁期间对中性刺激的反应发生改变，响应潜在威胁的终末纹连接的床核，以及与持续威胁相关的威胁响应。我们的评论得出结论，负效价系统在精神分裂症中改变；然而，更改的级别和证据因威胁响应的类型而异。我们提出了未来研究的途径，以进一步了解和干预精神分裂症的威胁反应。
