Abstract：
Critically ill septic patients present variable clinical trajectories, with some succumbing to hyperinflammatory responses while others develop a chronic critical illness, characterized by a prolonged low-grade inflammation, muscle atrophy, and mechanical ventilation dependency and often develop secondary infections often caused by from low-virulence microorganisms or reactivated latent viruses. The Seraph-100® hemoperfusion cartridge takes advantage from heparin-coated ultra-high molecular weight polyethylene microbeads mimicking pathogen-binding cell receptors and can adsorb both pathogens and damage-associated molecular patterns released by injured tissues. We describe two chronic critically ill patients who developed secondary viral bloodstream infections successfully treated with this device.
摘要：
危重的败血症患者呈现可变的临床轨迹，有些人屈服于高炎症反应，而另一些则发展为慢性危重疾病，以长期的低度炎症为特征，肌肉萎缩,和机械通气依赖性，并且经常发生继发感染，通常由低毒力微生物或再激活的潜伏病毒引起。Seraph-100®血液灌流盒利用肝素包被的超高分子量聚乙烯微珠模拟病原体结合细胞受体，可以吸附病原体和损伤组织释放的损伤相关分子模式。我们描述了两名成功使用该设备治疗的继发病毒性血流感染的慢性危重患者。
