{Reference Type}: Journal Article
{Title}: Hemoperfusion with high-affinity polyethylene microbeads (Seraph-100®) for the removal of pathogens in chronic critically ill patients: Clinical experience.
{Author}: Votrico V;Grilli M;Gerini U;Berlot G;
{Journal}: Int J Artif Organs
{Volume}: 47
{Issue}: 2
{Year}: 2024 Feb 5
{Factor}: 1.631
{DOI}: 10.1177/03913988231221405
{Abstract}: Critically ill septic patients present variable clinical trajectories, with some succumbing to hyperinflammatory responses while others develop a chronic critical illness, characterized by a prolonged low-grade inflammation, muscle atrophy, and mechanical ventilation dependency and often develop secondary infections often caused by from low-virulence microorganisms or reactivated latent viruses. The Seraph-100® hemoperfusion cartridge takes advantage from heparin-coated ultra-high molecular weight polyethylene microbeads mimicking pathogen-binding cell receptors and can adsorb both pathogens and damage-associated molecular patterns released by injured tissues. We describe two chronic critically ill patients who developed secondary viral bloodstream infections successfully treated with this device.