Abstract：
This study focuses on the latest developments in the studies of m6A modification and provides an up-to-date summary of the association between m6A modification and type 2 diabetes (T2D). The possible mechanisms of m6A related to T2D were summarized by literature review. The differentially expressed genes (DEGs) of m6A methylase in T2D were analyzed from 12 datasets in Gene Expression Omnibus (GEO). The associations between m6A level and T2D were explored in four electronic databases, including PubMed, EmBase, Web of Science and CNKI. Standard mean difference (SMD) and 95 % confidence interval (95 %CI) was calculated to assess the total effect in integrative analysis. Differential expression genes detected in at least three of six tissues were ZC3H13, YTHDC1/2, and IGF2BP2. LRPPRC were differentially expressed in five tissues except in arterial tissue. A total of 6 studies were included for integrative analysis. The mean m6A levels were significantly lower in T2D than those in normal controls (SMD = -1.35, 95 %CI: -2.58 to -0.11). This systematic review and integrative analysis summarize the previous studies on the association between m6A modification and T2D and the possible role of m6A modification in the progression of T2D, such as abnormal blood glucose, abnormal pancreatic β-cell function, insulin resistance, and abnormal lipid metabolism. The integrative analysis showed that decreased level of m6A was associated with T2D. These findings provide new targets for early detection and treatment for T2D.
摘要：
本研究重点介绍了m6A修饰研究的最新进展，并提供了m6A修饰与2型糖尿病（T2D）之间关联的最新摘要。通过文献综述总结了m6A与T2D相关的可能机制。从基因表达综合（GEO）的12个数据集中分析了T2D中m6A甲基化酶的差异表达基因（DEG）。在四个电子数据库中探索了m6A水平和T2D之间的关联，包括PubMed,Embase,WebofScience和CNKI.计算标准平均差（SMD）和95％置信区间（95CI）以评估综合分析中的总效果。在六个组织中的至少三个中检测到的差异表达基因是ZC3H13、YTHDC1/2和IGF2BP2。除动脉组织外，LRPPRC在五种组织中差异表达。共纳入6项研究进行综合分析。T2D患者平均m6A水平明显低于正常对照组(SMD=-1.35,95CI:-2.58~-0.11)。本系统综述和综合分析总结了以往关于m6A修饰与T2D之间的关联以及m6A修饰在T2D进展中的可能作用的研究。如血糖异常，胰腺β细胞功能异常，胰岛素抵抗，和异常的脂质代谢。综合分析表明，m6A水平降低与T2D相关。这些发现为T2D的早期检测和治疗提供了新的目标。
