Abstract：
QT prolongation is related to the development of ventricular arrhythmias such as Torsade de Pointes (TdP) that can lead to sudden cardiac death. Several drugs used in the treatment of patients with advanced cancer may induce QT prolongation due to their interference with cardiac ion channels. Some patients may be at higher risk if predisposing factors are present. Herein we present the case of a patient with advanced cancer under anti-tumor treatment with radical intention that developed a reversible drug-induced QT prolongation when simultaneously treated with methadone, haloperidol and fluoxetine that presented with chest pain and bradycardia. An approach to cancer patients at risk for drug-induced QT prolongation is discussed highlighting the need of a thorough medication review with a special focus in the patient with polypharmacy.
摘要：
QT延长与室性心律失常如尖端扭转(TdP)的发展有关,其可导致心源性猝死。用于治疗晚期癌症患者的几种药物可能由于其对心脏离子通道的干扰而引起QT延长。如果存在诱发因素，一些患者可能处于较高的风险。在这里，我们介绍了一个患有晚期癌症的患者的情况，该患者在接受抗肿瘤治疗时具有激进的意图，当同时使用美沙酮治疗时，出现了可逆的药物诱导的QT延长，氟哌啶醇和氟西汀表现为胸痛和心动过缓。讨论了一种针对有药物引起的QT延长风险的癌症患者的方法，强调需要进行全面的药物审查，并特别关注多药房患者。
