Abstract：
Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap are the third leading cause of mortality around the world. They share some common features, which can lead to misdiagnosis. To properly manage these conditions, reliable markers for early and accurate diagnosis are needed. Over the past 20 years, many molecules have been investigated in the exhaled breath condensate to better understand inflammation pathways and mechanisms related to these disorders. Recently, more advanced techniques, such as sensitive metabolomic and proteomic profiling, have been used to obtain a more comprehensive understanding. This article reviews the use of targeted and untargeted metabolomic methodology to study asthma, COPD and asthma-COPD overlap.
摘要：
哮喘,慢性阻塞性肺疾病(COPD)和哮喘-COPD重叠是全球第三大死亡原因.它们有一些共同的特点,这可能会导致误诊。为了妥善管理这些条件，早期和准确诊断的可靠标记是必要的。在过去的20年里,为了更好地了解与这些疾病相关的炎症途径和机制，已经在呼出气冷凝液中研究了许多分子。最近,更先进的技术，如敏感的代谢组学和蛋白质组学分析，已经被用来获得更全面的了解。本文综述了使用靶向和非靶向代谢组学方法研究哮喘，COPD和哮喘-COPD重叠。
