The sample included 2,390 community-dwelling Chinese participants. Their cognitive function was assessed using the Mini-Mental State Examination (MMSE). We defined a healthy lifestyle score on the basis of being non-smoking, performing ≥210 min/wk moderate/vigorous-intensity physical activity, having light to moderate alcohol consumption, eating vegetables and fruits daily, having a body mass index (BMI) of 18.5-23.9 kg/m2, and having a waist-to-hip ratio (WHR) <0.90 for men and <0.85 for women, for an overall score ranging from 0 to 6.
Compared with participants with ≤2 healthy lifestyle factors, the adjusted odds ratio (OR) and 95% confidence interval (CI) for participants with 4, 5, and 6 healthy lifestyle factors were 0.53 (95% CI, 0.29-0.98), 0.40 (95% CI, 0.21-0.75), and 0.36 (95% CI, 0.16-0.79), respectively. Only WHR (OR = 0.54, 95% CI = 0.37-0.78) and physical activity (OR = 0.69, 95% CI = 0.51-0.92) were associated with cognitive impairment. A healthy lifestyle correlated with overall cognition (β = 0.066, orientation (β = 0.049), language ability (β = 0.060), delayed recall (β = 0.045) and executive function (β = 0.044) (P all < 0.05).
The study provides evidence on an inverse association between healthy lifestyles and cognitive impairment. We investigated whether healthy lifestyle was related to specific cognitive functions to provide a theoretical basis for accurate clinical prescription.
■样本包括2390名社区居住的中国参与者。使用迷你精神状态检查(MMSE)评估他们的认知功能。我们在不吸烟的基础上定义了健康的生活方式评分,进行≥210分钟/周的中等/剧烈强度体力活动,轻度到中度饮酒,每天吃蔬菜和水果,体重指数(BMI)为18.5-23.9kg/m2,男性腰臀比(WHR)<0.90,女性<0.85,总分从0到6。
■与具有≤2种健康生活方式因素的参与者相比,有4、5和6个健康生活方式因素的参与者的调整比值比(OR)和95%置信区间(CI)为0.53(95%CI,0.29-0.98),0.40(95%CI,0.21-0.75),和0.36(95%CI,0.16-0.79),分别。只有WHR(OR=0.54,95%CI=0.37-0.78)和体力活动(OR=0.69,95%CI=0.51-0.92)与认知障碍相关。健康的生活方式与整体认知相关(β=0.066,取向(β=0.049),语言能力(β=0.060),延迟回忆(β=0.045)和执行功能(β=0.044)(P均<0.05)。
■该研究提供了健康生活方式与认知障碍之间负相关的证据。我们调查健康的生活方式是否与特定的认知功能有关,为临床准确处方提供理论依据。