关键词: amelogenesis imperfecta children classification etiology genotype phenotype rare condition restorative dentistry

来  源:   DOI:10.7759/cureus.49968   PDF(Pubmed)

Abstract:
Amelogenesis imperfecta (AI) is a rare genetic disorder affecting children and adults. Knowledge about AI is limited to clinical representation and radiographical findings. Various treatments are provided to children with AI, yet no definitive treatment guideline has been suggested in the literature. This scoping review highlights the knowledge of the etiology and classification of AI and synthesizes these findings in a comprehensive review, focusing mainly on the various forms of AI in children and management with a restorative conservative approach. Five electronic databases, namely, PubMed, Google Scholar, Embase, Web of Science, and Scopus, were searched for the relevant articles. The search was performed in two phases: first for title and abstract, and second for full-text articles. The studies included in this scoping review were published from 2013 to August 2023. The data extraction was done on a customized sheet. A total of 33 studies were included in this review, of which 19 were reports and series, seven were observational, and seven were reviews. Most patients included in this review suffered from the hypoplastic type of AI (54%), followed by hypomatured (36%), and hypocalcified (10%). The treatment modalities explained were divided into the following three phases: temporary, transient, and permanent. Almost all included reports suggested the requirement for guidelines for treating AI among young children. This scoping review suggests the need for guidelines for treating AI in children. Moreover, pediatric dentists should prioritize early diagnosis and treatment and long-term follow-up for AI in children to effectively enhance the patient\'s psychological well-being and overall quality of life.
摘要:
成釉细胞发育不全(AI)是一种罕见的遗传性疾病,影响儿童和成人。有关AI的知识仅限于临床表现和影像学发现。为患有AI的儿童提供各种治疗,然而,文献中尚未提出明确的治疗指南.本范围审查强调了AI的病因和分类的知识,并在全面审查中综合了这些发现,主要关注儿童中各种形式的人工智能,并采用恢复性保守的方法进行管理。五个电子数据库,即,PubMed,谷歌学者,Embase,WebofScience,还有Scopus,搜索了相关文章。搜索分两个阶段进行:首先是标题和摘要,其次是全文文章。本范围审查中包含的研究发表于2013年至2023年8月。在定制的工作表上进行数据提取。本综述共纳入33项研究,其中19份是报告和系列,七个是观察性的,七个是评论。本综述中包括的大多数患者患有发育不良型AI(54%),其次是低血(36%),钙化不足(10%)。解释的治疗方式分为以下三个阶段:临时,瞬态,和永久的。几乎所有报告都提出了在幼儿中治疗人工智能的指南要求。这项范围审查表明,有必要制定儿童AI治疗指南。此外,儿科牙医应优先考虑儿童AI的早期诊断和治疗以及长期随访,以有效提高患者的心理健康和整体生活质量。
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