PDF(Pubmed)
Abstract：
UNASSIGNED: The association between women\'s stress and pregnancy glucose levels remain unclear, specifically when considering the preconception period as a sensitive window of exposure.
UNASSIGNED: We investigated whether preconception perceived stress was associated with glucose levels during pregnancy among women attending a fertility center (2004-2019).
UNASSIGNED: Before conception, women completed a psychological stress survey using the short version of the validated Perceived Stress Scale 4 (PSS-4), and blood glucose was measured using a 50-gram glucose load test during late pregnancy as a part of screening for gestational diabetes. Linear and log-binomial regression models were used to assess associations of total PSS-4 scores with mean glucose levels and abnormal glucose levels ( ≥ 140 mg/dL), adjusting for age, body mass index, race, smoking, education, physical activity, primary infertility diagnosis, number of babies, and mode of conception.
UNASSIGNED: Psychological stress was positively associated with mean abnormal glucose levels. The adjusted marginal means (95% CI) of mean glucose levels for women in the first, second, and third tertiles of psychological stress were 115 (110, 119), 119 (115, 123), and 124 (119, 128), and mg/dL, respectively (P for trend = .007). Also, women in the second and third tertiles of psychological stress had 4% and 13% higher probabilities of having abnormal glucose compared with women in the first tertile of psychological stress (P trend = .01).
UNASSIGNED: These results highlight the importance of considering preconception when evaluating the relationship between women\'s stress and pregnancy glucose levels.
UNASSIGNED: We investigated whether preconception perceived stress was associated with glucose levels during pregnancy among women attending a fertility center (2004-2019).
UNASSIGNED: Before conception, women completed a psychological stress survey using the short version of the validated Perceived Stress Scale 4 (PSS-4), and blood glucose was measured using a 50-gram glucose load test during late pregnancy as a part of screening for gestational diabetes. Linear and log-binomial regression models were used to assess associations of total PSS-4 scores with mean glucose levels and abnormal glucose levels ( ≥ 140 mg/dL), adjusting for age, body mass index, race, smoking, education, physical activity, primary infertility diagnosis, number of babies, and mode of conception.
UNASSIGNED: Psychological stress was positively associated with mean abnormal glucose levels. The adjusted marginal means (95% CI) of mean glucose levels for women in the first, second, and third tertiles of psychological stress were 115 (110, 119), 119 (115, 123), and 124 (119, 128), and mg/dL, respectively (P for trend = .007). Also, women in the second and third tertiles of psychological stress had 4% and 13% higher probabilities of having abnormal glucose compared with women in the first tertile of psychological stress (P trend = .01).
UNASSIGNED: These results highlight the importance of considering preconception when evaluating the relationship between women\'s stress and pregnancy glucose levels.
摘要：
■女性的压力与妊娠血糖水平之间的关系尚不清楚，特别是当考虑将孕前时期作为暴露的敏感窗口时。
■我们调查了在生育中心就诊的女性（2004-2019年）中，孕前感知的压力是否与怀孕期间的血糖水平有关。
■在受孕之前，女性使用经过验证的感知压力量表4（PSS-4）的简短版本完成了心理压力调查，在妊娠晚期使用50克葡萄糖负荷试验测量血糖,作为妊娠期糖尿病筛查的一部分.线性和对数二项回归模型用于评估总PSS-4评分与平均葡萄糖水平和异常葡萄糖水平（≥140mg/dL）的关联。调整年龄，身体质量指数,种族,吸烟,教育,身体活动,原发性不孕症诊断，婴儿的数量,和概念模式。
■心理压力与平均血糖异常水平呈正相关。第一，女性平均血糖水平的调整边际均值(95%CI)，第二,心理压力的第三个三元是115(110，119)，119(115,123),和124（119，128），和mg/dL，分别(趋势的P=0.007)。此外，与心理压力第一三分位的女性相比,心理压力第二和第三三分位的女性发生血糖异常的概率分别高出4%和13%(P趋势=.01).
■这些结果强调了在评估女性压力与妊娠血糖水平之间关系时考虑孕前的重要性。
■我们调查了在生育中心就诊的女性（2004-2019年）中，孕前感知的压力是否与怀孕期间的血糖水平有关。
■在受孕之前，女性使用经过验证的感知压力量表4（PSS-4）的简短版本完成了心理压力调查，在妊娠晚期使用50克葡萄糖负荷试验测量血糖,作为妊娠期糖尿病筛查的一部分.线性和对数二项回归模型用于评估总PSS-4评分与平均葡萄糖水平和异常葡萄糖水平（≥140mg/dL）的关联。调整年龄，身体质量指数,种族,吸烟,教育,身体活动,原发性不孕症诊断，婴儿的数量,和概念模式。
■心理压力与平均血糖异常水平呈正相关。第一，女性平均血糖水平的调整边际均值(95%CI)，第二,心理压力的第三个三元是115(110，119)，119(115,123),和124（119，128），和mg/dL，分别(趋势的P=0.007)。此外，与心理压力第一三分位的女性相比,心理压力第二和第三三分位的女性发生血糖异常的概率分别高出4%和13%(P趋势=.01).
■这些结果强调了在评估女性压力与妊娠血糖水平之间关系时考虑孕前的重要性。
