Abstract：
OBJECTIVE: Despite mounting evidence demonstrates circulating endothelial progenitor cells (cEPCs) quantitative changes in depression, no study has investigated cEPC functions in major depressive disorder (MDD). We investigated the role of cEPC adhesive and apoptotic functions in MDD.
METHODS: We recruited 68 patients with MDD and 56 healthy controls (HCs). The depression symptoms, anxiety, psychosomatic symptoms, subjective cognitive dysfunction, quality of life, and functional disability were evaluated using the Hamilton Depression Rating Scale and Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, Depression and Somatic Symptoms Scale (DSSS), Perceived Deficits Questionnaire-Depression, 12-Item Short Form Health Survey (SF-12), and Sheehan Disability Scale (SDS), respectively. Working memory and executive function were assessed using a 2-back task and Wisconsin Card Sorting Test (WCST). Inflammatory marker (soluble interleukin-6 receptor, C-reactive protein, and tumor necrosis factor-α receptor-1), cEPC adhesive, and apoptotic levels were measured using in vitro assays.
RESULTS: The MDD patients showed significantly lower cEPC adhesive levels than the HCs, and this difference in adhesive function remained statistically significant even after adjusting for inflammatory marker levels. The cEPC adhesion levels were in inverse correlations with commission and omission errors in 2-back task, the percent perseverative response and percent perseverative errors in WCST, and the DSSS and SDS scores, but in positive correlations with SF-12 physical and mental component scores. cEPC apoptotic levels did not differ significantly between the groups.
CONCLUSIONS: The findings indicate that cEPC adhesive function is diminished in MDD and impacts various aspects of cognitive and psychosocial functions associated with the disorder.
METHODS: We recruited 68 patients with MDD and 56 healthy controls (HCs). The depression symptoms, anxiety, psychosomatic symptoms, subjective cognitive dysfunction, quality of life, and functional disability were evaluated using the Hamilton Depression Rating Scale and Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, Depression and Somatic Symptoms Scale (DSSS), Perceived Deficits Questionnaire-Depression, 12-Item Short Form Health Survey (SF-12), and Sheehan Disability Scale (SDS), respectively. Working memory and executive function were assessed using a 2-back task and Wisconsin Card Sorting Test (WCST). Inflammatory marker (soluble interleukin-6 receptor, C-reactive protein, and tumor necrosis factor-α receptor-1), cEPC adhesive, and apoptotic levels were measured using in vitro assays.
RESULTS: The MDD patients showed significantly lower cEPC adhesive levels than the HCs, and this difference in adhesive function remained statistically significant even after adjusting for inflammatory marker levels. The cEPC adhesion levels were in inverse correlations with commission and omission errors in 2-back task, the percent perseverative response and percent perseverative errors in WCST, and the DSSS and SDS scores, but in positive correlations with SF-12 physical and mental component scores. cEPC apoptotic levels did not differ significantly between the groups.
CONCLUSIONS: The findings indicate that cEPC adhesive function is diminished in MDD and impacts various aspects of cognitive and psychosocial functions associated with the disorder.
摘要：
目的：尽管有大量证据表明循环内皮祖细胞（cEPCs）在抑郁症中的数量变化，尚无研究调查重度抑郁症（MDD）的cEPC功能。我们研究了cEPC粘附和凋亡功能在MDD中的作用。
方法：我们招募了68例MDD患者和56例健康对照（HCs）。抑郁症状,焦虑,心身症状,主观认知功能障碍，生活质量,使用汉密尔顿抑郁量表和蒙哥马利-奥斯贝格抑郁量表评估功能障碍，汉密尔顿焦虑量表，抑郁症和躯体症状量表（DSSS），感知赤字问卷-抑郁症，12项简式健康调查(SF-12)，和希恩残疾量表(SDS)，分别。使用2回任务和威斯康星卡片分类测试（WCST）评估工作记忆和执行功能。炎症标志物（可溶性白细胞介素6受体，C反应蛋白,和肿瘤坏死因子-α受体-1），使用体外测定法测量cEPC粘附和凋亡水平。
结果：MDD患者的cEPC胶粘剂水平明显低于HC，即使在调整炎症标志物水平后，粘附功能的这种差异仍具有统计学意义。cEPC粘附水平与2-back任务中的委托和遗漏错误呈负相关，WCST中持续响应的百分比和持续错误的百分比，以及DSSS和SDS评分，但与SF-12身心成分得分呈正相关。cEPC凋亡水平在两组之间没有显着差异。
结论：研究结果表明，MDD中cEPC粘附功能减弱，并影响与该疾病相关的认知和心理社会功能的各个方面。
方法：我们招募了68例MDD患者和56例健康对照（HCs）。抑郁症状,焦虑,心身症状,主观认知功能障碍，生活质量,使用汉密尔顿抑郁量表和蒙哥马利-奥斯贝格抑郁量表评估功能障碍，汉密尔顿焦虑量表，抑郁症和躯体症状量表（DSSS），感知赤字问卷-抑郁症，12项简式健康调查(SF-12)，和希恩残疾量表(SDS)，分别。使用2回任务和威斯康星卡片分类测试（WCST）评估工作记忆和执行功能。炎症标志物（可溶性白细胞介素6受体，C反应蛋白,和肿瘤坏死因子-α受体-1），使用体外测定法测量cEPC粘附和凋亡水平。
结果：MDD患者的cEPC胶粘剂水平明显低于HC，即使在调整炎症标志物水平后，粘附功能的这种差异仍具有统计学意义。cEPC粘附水平与2-back任务中的委托和遗漏错误呈负相关，WCST中持续响应的百分比和持续错误的百分比，以及DSSS和SDS评分，但与SF-12身心成分得分呈正相关。cEPC凋亡水平在两组之间没有显着差异。
结论：研究结果表明，MDD中cEPC粘附功能减弱，并影响与该疾病相关的认知和心理社会功能的各个方面。
