PDF(Pubmed)
Abstract：
Metal immunotherapy is a novel adjuvant immunotherapy. Mn2+ can activate STING-a type I IFN response protein-that promotes innate immunity and increases anti-tumor activity by promoting macrophage phagocytosis. IL-12, a cytokine that increases the antigen-presenting ability to promote effector T-cell activation, has potent antitumor activity, albeit with severe adverse effects. In this study, we observed that the combination of Mn2+ and IL-12 has a better antitumor effect and possibly reflects a better safety profile, providing a novel approach and theoretical basis for safe and rapid cancer treatment.
摘要：
金属免疫疗法是一种新型的辅助性免疫疗法。Mn2可以激活STING-一种I型IFN反应蛋白-通过促进巨噬细胞吞噬作用来促进先天免疫并增加抗肿瘤活性。IL-12，一种增加抗原呈递能力以促进效应T细胞活化的细胞因子，具有强大的抗肿瘤活性，尽管有严重的不良影响。在这项研究中,我们观察到Mn2+和IL-12的组合具有更好的抗肿瘤作用，并可能反映出更好的安全性，为肿瘤的安全、快速治疗提供了新的方法和理论依据。
