%0 Journal Article
%T Manganese and IL-12 treatment alters the ovarian tumor microenvironment.
%A Xu Y
%A Huang X
%A Nie XC
%A Liu YS
%A Zhou Y
%A Niu JM
%J Aging (Albany NY)
%V 16
%N 1
%D 2024 01 3
%M 38175694
%F 5.955
%R 10.18632/aging.205361
%X Metal immunotherapy is a novel adjuvant immunotherapy. Mn2+ can activate STING-a type I IFN response protein-that promotes innate immunity and increases anti-tumor activity by promoting macrophage phagocytosis. IL-12, a cytokine that increases the antigen-presenting ability to promote effector T-cell activation, has potent antitumor activity, albeit with severe adverse effects. In this study, we observed that the combination of Mn2+ and IL-12 has a better antitumor effect and possibly reflects a better safety profile, providing a novel approach and theoretical basis for safe and rapid cancer treatment.