Abstract：
UNASSIGNED: Histopathological examination of the effects of Tisseel, Cova, Glubran and Coseal, which are used for sealing purposes in spinal surgery practice, on epidural fibrosis is aimed.
UNASSIGNED: Forty Sprague Dawley rats were randomly divided into five groups in our study as Group 1 (n=8) control group (Laminectomy); Group 2 (n=8) Cova group (Laminectomy + Cova); Group 3 (n=8) Tissel group (Laminectomy + Tisseel); Group 4 (n=8) Coseal group (Laminectomy + Coseal); and Group 5 Glubrane group (Laminectomy + Glubrane). Control group was only applied laminectomy. After laminectomy to other groups, Cova was applied to the 2nd group, Tissel to the 3rd group, Coseal to the 4th group and Glubran to the 5th group in surgical fields. After the rats were monitored in separate cages for 6 weeks after the operation, the relevant spinal level was extracted and the samples were examined histopathologically and the results were evaluated statistically.
UNASSIGNED: It was found that there was a statistically significant difference in Tisseel and Glubran groups in terms of fibrosis grading compared to the control group, and this had a positive effect on fibrosis. Compared to the control group, there was no statistically significant difference on fibrosis in Cova and Coseal groups.
UNASSIGNED: As dura adhesive agents used in spinal surgery practice did not increase spinal epidural fibrosis statistically significantly, we concluded that these products can be used safely during spinal surgery if necessary.
UNASSIGNED: Forty Sprague Dawley rats were randomly divided into five groups in our study as Group 1 (n=8) control group (Laminectomy); Group 2 (n=8) Cova group (Laminectomy + Cova); Group 3 (n=8) Tissel group (Laminectomy + Tisseel); Group 4 (n=8) Coseal group (Laminectomy + Coseal); and Group 5 Glubrane group (Laminectomy + Glubrane). Control group was only applied laminectomy. After laminectomy to other groups, Cova was applied to the 2nd group, Tissel to the 3rd group, Coseal to the 4th group and Glubran to the 5th group in surgical fields. After the rats were monitored in separate cages for 6 weeks after the operation, the relevant spinal level was extracted and the samples were examined histopathologically and the results were evaluated statistically.
UNASSIGNED: It was found that there was a statistically significant difference in Tisseel and Glubran groups in terms of fibrosis grading compared to the control group, and this had a positive effect on fibrosis. Compared to the control group, there was no statistically significant difference on fibrosis in Cova and Coseal groups.
UNASSIGNED: As dura adhesive agents used in spinal surgery practice did not increase spinal epidural fibrosis statistically significantly, we concluded that these products can be used safely during spinal surgery if necessary.
摘要：
■Tisseel影响的组织病理学检查，Cova,Glubran和Coseal，在脊柱外科手术中用于密封目的，针对硬膜外纤维化。
■在我们的研究中，将40只SpragueDawley大鼠随机分为五组，即第1组（n=8）对照组（椎板切除术）；第2组（n=8）Cova组（椎板切除术+Cova）；第3组（n=8）Tissel组（椎板切除术+Tisseel）；第4组（n=8）对照组仅应用椎板切除术。在对其他组进行椎板切除术后，Cova被应用于第二组，Tissel到第三组,在手术领域，第4组的Coseal和第5组的Glubran。术后6周分别对大鼠进行笼内监测,提取相关的脊柱水平，对样本进行组织病理学检查，并对结果进行统计学评估。
■发现Tisseel和Glarwan组在纤维化分级方面与对照组相比有统计学上的显着差异，这对纤维化有积极的影响。与对照组相比,Cova组和Coseal组纤维化差异无统计学意义。
■由于脊柱外科手术中使用的硬脑膜粘合剂在统计学上没有显着增加脊髓硬膜外纤维化，我们得出的结论是，如果有必要，这些产品可以在脊柱手术中安全使用。
■在我们的研究中，将40只SpragueDawley大鼠随机分为五组，即第1组（n=8）对照组（椎板切除术）；第2组（n=8）Cova组（椎板切除术+Cova）；第3组（n=8）Tissel组（椎板切除术+Tisseel）；第4组（n=8）对照组仅应用椎板切除术。在对其他组进行椎板切除术后，Cova被应用于第二组，Tissel到第三组,在手术领域，第4组的Coseal和第5组的Glubran。术后6周分别对大鼠进行笼内监测,提取相关的脊柱水平，对样本进行组织病理学检查，并对结果进行统计学评估。
■发现Tisseel和Glarwan组在纤维化分级方面与对照组相比有统计学上的显着差异，这对纤维化有积极的影响。与对照组相比,Cova组和Coseal组纤维化差异无统计学意义。
■由于脊柱外科手术中使用的硬脑膜粘合剂在统计学上没有显着增加脊髓硬膜外纤维化，我们得出的结论是，如果有必要，这些产品可以在脊柱手术中安全使用。
