PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have reported that transcription factor forkhead box protein 3 (FOXP3) polymorphisms are correlated with the progress of some cancers, but the relationships between the FOXP3 polymorphisms and hepatocellular carcinoma (HCC) risk remain unclear.
UNASSIGNED: Genotypes were detected in156 hepatitis B virus (HBV)-HCC patients, 109 HBV-liver cirrhosis (LC) patients, 125 chronic hepatitis B (CHB) patients, and 188 healthy controls. The FOXP3 rs3761547 and rs3761548 polymorphisms were genotyped by polymerase chain reaction (PCR) combined with restriction fragment length polymorphism, and the rs2232365 polymorphism was genotyped using PCR with sequence-specific primers.
UNASSIGNED: We did not obtain any significant results with the FOXP3 rs3761547, rs3761548, and rs2232365 polymorphisms in groups of patients compared to healthy controls (all p > 0.05), no matter the overall group or subgroup.
UNASSIGNED: Our findings suggest that the FOXP3 polymorphisms at rs3761547, rs3761548, and rs2232365 were not related to HBV-HCC risk in the Chinese population.
UNASSIGNED: Genotypes were detected in156 hepatitis B virus (HBV)-HCC patients, 109 HBV-liver cirrhosis (LC) patients, 125 chronic hepatitis B (CHB) patients, and 188 healthy controls. The FOXP3 rs3761547 and rs3761548 polymorphisms were genotyped by polymerase chain reaction (PCR) combined with restriction fragment length polymorphism, and the rs2232365 polymorphism was genotyped using PCR with sequence-specific primers.
UNASSIGNED: We did not obtain any significant results with the FOXP3 rs3761547, rs3761548, and rs2232365 polymorphisms in groups of patients compared to healthy controls (all p > 0.05), no matter the overall group or subgroup.
UNASSIGNED: Our findings suggest that the FOXP3 polymorphisms at rs3761547, rs3761548, and rs2232365 were not related to HBV-HCC risk in the Chinese population.
摘要：
■以前的研究报道转录因子叉头盒蛋白3（FOXP3）多态性与某些癌症的进展有关，但FOXP3多态性与肝细胞癌（HCC）风险之间的关系仍不清楚。
■在156例乙型肝炎病毒（HBV）-HCC患者中检测到基因型，109HBV肝硬化（LC）患者，125慢性乙型肝炎（CHB）患者，和188个健康对照。通过聚合酶链反应（PCR）结合限制性片段长度多态性对FOXP3rs3761547和rs3761548多态性进行基因分型，用序列特异性引物进行PCR对rs2232365多态性进行基因分型。
■与健康对照组相比，我们在患者组中的FOXP3rs3761547，rs3761548和rs222365多态性未获得任何显着结果（均p>0.05），无论是整体组还是亚组。
■我们的研究结果表明，在中国人群中，rs3761547，rs3761548和rs222365的FOXP3多态性与HBV-HCC风险无关。
■在156例乙型肝炎病毒（HBV）-HCC患者中检测到基因型，109HBV肝硬化（LC）患者，125慢性乙型肝炎（CHB）患者，和188个健康对照。通过聚合酶链反应（PCR）结合限制性片段长度多态性对FOXP3rs3761547和rs3761548多态性进行基因分型，用序列特异性引物进行PCR对rs2232365多态性进行基因分型。
■与健康对照组相比，我们在患者组中的FOXP3rs3761547，rs3761548和rs222365多态性未获得任何显着结果（均p>0.05），无论是整体组还是亚组。
■我们的研究结果表明，在中国人群中，rs3761547，rs3761548和rs222365的FOXP3多态性与HBV-HCC风险无关。
