HIV-associated CD8+ T-cell Skin Infiltrative Disease and EBV-associated Polymorphic B-cell Lymphoproliferative Disorder in an AIDS Patient Who Improved Dramatically with Antiretroviral Therapy Alone.

HIV 相关的 CD8 + T 细胞皮肤浸润性疾病和 EBV 相关的多形性 B 细胞淋巴增殖性疾病在艾滋病患者中的应用 ， 这些患者单独使用抗逆转录病毒疗法获得了明显改善。

• 影响指数: 1.282
• 发表时间: 2024 Aug 1
• 来源期刊: Intern Med
• DOI: 10.2169/internalmedicine.2687-23
• PMID: 38171853
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Okada N,Saito K,Watanabe M,Ohtani T,Notohara K,Wada H,Ueda Y

关键词: EBV-associated polymorphic B-cell lymphoproliferative disorder; HIV-associated CD8+ T-cell skin infiltrative disease; antiretroviral therapy; erythroderma

Mesh: Humans; Male; Adult; CD8-Positive T-Lymphocytes / immunology; Epstein-Barr Virus Infections / complications immunology drug therapy; Lymphoproliferative Disorders / drug therapy immunology diagnosis; Acquired Immunodeficiency Syndrome / drug therapy complications immunology; Herpesvirus 4, Human / immunology; HIV Infections / drug therapy complications immunology; Treatment Outcome; Antiretroviral Therapy, Highly Active; B-Lymphocytes / immunology

Abstract

Human immunodeficiency virus (HIV)-associated CD8+ T-cell skin infiltrative disease with severe erythroderma has rarely been reported. While HIV-positive patients are prone to develop lymphoma, which is often associated with Epstein-Barr virus, polymorphic lymphoproliferative disorder is rare, accounting for <5% of cases. We herein report a 41-year-old HIV-positive man who presented with a fever, erythroderma, and lymphadenopathy and was diagnosed with the coexistence of both diseases. His condition improved significantly with continued antiretroviral therapy. This case suggests that HIV-induced immunodeficiency is central to the pathogenesis of both entities and that improvement of the immunodeficient state is an effective treatment.

摘要

人类免疫缺陷病毒（HIV）相关的CD8T细胞皮肤浸润性疾病伴严重红皮病的报道很少。虽然HIV阳性患者容易患上淋巴瘤，通常与爱泼斯坦-巴尔病毒有关，多形性淋巴增生性疾病是罕见的，占病例的5%。我们在此报告一名41岁的HIV阳性男子，他出现了发烧，红皮病,和淋巴结病，并被诊断为两种疾病并存。通过持续的抗逆转录病毒治疗，他的病情明显改善。这种情况表明，HIV诱导的免疫缺陷对两种实体的发病机理至关重要，并且改善免疫缺陷状态是有效的治疗方法。