{Reference Type}: Case Reports
{Title}: HIV-associated CD8+ T-cell Skin Infiltrative Disease and EBV-associated Polymorphic B-cell Lymphoproliferative Disorder in an AIDS Patient Who Improved Dramatically with Antiretroviral Therapy Alone.
{Author}: Okada N;Saito K;Watanabe M;Ohtani T;Notohara K;Wada H;Ueda Y;
{Journal}: Intern Med
{Volume}: 63
{Issue}: 15
{Year}: 2024 Aug 1
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.2687-23
{Abstract}: Human immunodeficiency virus (HIV)-associated CD8+ T-cell skin infiltrative disease with severe erythroderma has rarely been reported. While HIV-positive patients are prone to develop lymphoma, which is often associated with Epstein-Barr virus, polymorphic lymphoproliferative disorder is rare, accounting for <5% of cases. We herein report a 41-year-old HIV-positive man who presented with a fever, erythroderma, and lymphadenopathy and was diagnosed with the coexistence of both diseases. His condition improved significantly with continued antiretroviral therapy. This case suggests that HIV-induced immunodeficiency is central to the pathogenesis of both entities and that improvement of the immunodeficient state is an effective treatment.