Retrospective cohort study.
The observational cohort study was conducted at Soochow University Affiliated Children\'s Hospital from January 2017 to June 2021 and involved 132 797 children born in 2017 or 2018. They were followed and identified CAP episodes by screening on the Health Information Systems of outpatients and inpatients in the same hospital.
The CAP episodes were defined when the diagnoses coded as J09-J18 or J20-J22. The incidence of CAP was estimated stratified by age, sex, birth year, health status group, season and month, and the rate ratio was calculated and adjusted by a quasi-Poisson regression model. Stratified analysis of incidence of CAP by birth month was conducted to understand the age and seasonal variation.
The overall incidence of CAP among children aged ≤5 years was 130.08 per 1000 person years. Children aged ≤24 months have a higher CAP incidence than those aged >24 months (176.84 vs 72.04 per 1000 person years, p<0.001). The CAP incidence increased from October, peaked at December and January and the highest CAP incidence was observed in winter (206.7 per 1000 person years, 95% CI 204.12 to 209.28). A substantial decline of CAP incidence was observed during the COVID-19 lockdown from February to August 2020, and began to rise again when the communities reopened.
The burden of CAP among children is considerable. The incidence of CAP among children ≤5 years varied by age and season and decreased during COVID-19 lockdown.
方法:回顾性队列研究。
方法:观察性队列研究于2017年1月至2021年6月在苏州大学附属儿童医院进行,纳入2017年或2018年出生的132797名儿童。通过在同一家医院的门诊患者和住院患者的健康信息系统上进行筛查,对他们进行随访并确定了CAP发作。
结果:当诊断编码为J09-J18或J20-J22时,定义CAP发作。CAP的发病率按年龄分层估计,性别,出生年份,健康状况组,季节和月份,并通过准泊松回归模型计算和调整比率。按出生月份对CAP发病率进行分层分析,了解其年龄和季节变化。
结果:≤5岁儿童的总CAP发生率为130.08/1000人年。年龄≤24个月的儿童的CAP发生率高于年龄>24个月的儿童(176.84vs72.04/1000人年,p<0.001)。CAP发病率从10月份开始增加,在12月和1月达到峰值,在冬季观察到最高的CAP发病率(每1000人年206.7,95%CI204.12至209.28)。在2020年2月至8月的COVID-19封锁期间,CAP发病率大幅下降,当社区重新开放时,CAP发病率又开始上升。
结论:儿童的CAP负担相当大。≤5岁儿童的CAP发病率因年龄和季节而异,在COVID-19封锁期间有所下降。