PDF(Pubmed)
Abstract：
Diabetes mellitus is a prevalent chronic condition that significantly impacts global health. Diabetic foot complications, such as foot ulcers, pose a substantial burden on individuals with diabetes and can lead to serious consequences, including amputation. Platelet-rich plasma (PRP) has emerged as a promising therapeutic approach for enhancing the healing of diabetic foot ulcers.
In our study, we treated 12 patients with chronic diabetic ulcers using PRP injections administered at three-week intervals. Our objective was to assess the reduction in wound size and the rate of complete healing at 6 months after the start of the treatment. Additionally, we conducted a comprehensive literature review to contextualize our findings.
Out of the 12 patients, 8 achieved complete healing of their diabetic foot ulcers, while the remaining four showed significant improvement with more than 50% reduction in the initial lesion size. 3 patients developed mild irritation at the inoculation site. These outcomes, combined with the evidence from published studies, highlight the effectiveness of PRP in promoting the healing of diabetic foot ulcers.
In conclusion, our study demonstrates the potential of platelet-rich plasma (PRP) as a successful therapeutic option for enhancing the healing process of chronic diabetic foot ulcers. The favorable outcomes observed, including a high rate of complete healing and significant wound size reduction, underscore the value of PRP treatment in managing this challenging complication. Further research and larger studies may provide additional insights into the mechanisms and long-term benefits of PRP in diabetic wound healing.
In our study, we treated 12 patients with chronic diabetic ulcers using PRP injections administered at three-week intervals. Our objective was to assess the reduction in wound size and the rate of complete healing at 6 months after the start of the treatment. Additionally, we conducted a comprehensive literature review to contextualize our findings.
Out of the 12 patients, 8 achieved complete healing of their diabetic foot ulcers, while the remaining four showed significant improvement with more than 50% reduction in the initial lesion size. 3 patients developed mild irritation at the inoculation site. These outcomes, combined with the evidence from published studies, highlight the effectiveness of PRP in promoting the healing of diabetic foot ulcers.
In conclusion, our study demonstrates the potential of platelet-rich plasma (PRP) as a successful therapeutic option for enhancing the healing process of chronic diabetic foot ulcers. The favorable outcomes observed, including a high rate of complete healing and significant wound size reduction, underscore the value of PRP treatment in managing this challenging complication. Further research and larger studies may provide additional insights into the mechanisms and long-term benefits of PRP in diabetic wound healing.
摘要：
糖尿病是一种普遍的慢性病，对全球健康有显著影响。糖尿病足并发症,比如足部溃疡，对糖尿病患者造成沉重负担，并可能导致严重后果，包括截肢.富血小板血浆（PRP）已成为增强糖尿病足溃疡愈合的有希望的治疗方法。
■在我们的研究中，我们使用PRP注射治疗12例慢性糖尿病性溃疡患者,每次间隔3周.我们的目的是评估伤口大小的减少和治疗开始后6个月的完全愈合率。此外,我们进行了全面的文献综述,以了解我们的研究结果.
■在12名患者中，8实现了他们的糖尿病足溃疡的完全愈合，而其余四个显示显着改善，初始病变大小减少了50％以上。3名患者在接种部位出现轻度刺激。这些结果,结合已发表研究的证据，强调PRP促进糖尿病足溃疡愈合的有效性。
■总而言之，我们的研究表明,富血小板血浆(PRP)有可能作为一种成功的治疗选择,用于增强慢性糖尿病足溃疡的愈合过程.观察到的有利结果，包括高的完全愈合率和显著的伤口大小减小，强调PRP治疗在处理这一具有挑战性的并发症中的价值.进一步的研究和更大的研究可能为PRP在糖尿病伤口愈合中的机制和长期益处提供更多的见解。
■在我们的研究中，我们使用PRP注射治疗12例慢性糖尿病性溃疡患者,每次间隔3周.我们的目的是评估伤口大小的减少和治疗开始后6个月的完全愈合率。此外,我们进行了全面的文献综述,以了解我们的研究结果.
■在12名患者中，8实现了他们的糖尿病足溃疡的完全愈合，而其余四个显示显着改善，初始病变大小减少了50％以上。3名患者在接种部位出现轻度刺激。这些结果,结合已发表研究的证据，强调PRP促进糖尿病足溃疡愈合的有效性。
■总而言之，我们的研究表明,富血小板血浆(PRP)有可能作为一种成功的治疗选择,用于增强慢性糖尿病足溃疡的愈合过程.观察到的有利结果，包括高的完全愈合率和显著的伤口大小减小，强调PRP治疗在处理这一具有挑战性的并发症中的价值.进一步的研究和更大的研究可能为PRP在糖尿病伤口愈合中的机制和长期益处提供更多的见解。
