PDF(Pubmed)
Abstract：
UNASSIGNED: A Fabry-Perot (FP) polymer film sensor can be used to detect acoustic waves in a photoacoustic endoscope (PAE) if the dimensions can be adequately scaled down in size. Current FP sensors have limitations in size, sensitivity, and array configurability.
UNASSIGNED: We aim to characterize and demonstrate the imaging performance of a miniature FP sensor to evaluate the effects of reduced size and finite dimensions.
UNASSIGNED: A transfer matrix model was developed to characterize the frequency response of a multilayer miniature FP sensor. An analytical model was derived to describe the effects of a substrate with finite thickness. Finite-element analysis was performed to characterize the temporal response of a sensor with finite dimensions. Miniature 2×2 mm2 FP sensors were designed and fabricated using gold films as reflective mirrors on either side of a parylene C film deposited on a glass wafer. A single-wavelength laser was used to interrogate the sensor using illumination delivered by fiber subprobes. Imaging phantoms were used to verify FP sensor performance, and in vivo images of blood vessels were collected from a live mouse.
UNASSIGNED: The finite thickness substrate of the FP sensor resulted in echoes in the time domain signal that could be removed by back filtering. The substrate acted as a filter in the frequency domain. The finite lateral sensor dimensions produced side waves that could be eliminated by surface averaging using an interrogation beam with adequate diameter. The fabricated FP sensor produced a noise-equivalent pressure = 0.76 kPa, bandwidth of 16.6 MHz, a spectral full-width at-half-maximum = 0.2886 nm, and quality factor Q=2694. Photoacoustic images were collected from phantoms and blood vessels in a live mouse.
UNASSIGNED: A miniature wafer-based FP sensor design has been demonstrated with scaled down form factor for future use in PAE.
UNASSIGNED: We aim to characterize and demonstrate the imaging performance of a miniature FP sensor to evaluate the effects of reduced size and finite dimensions.
UNASSIGNED: A transfer matrix model was developed to characterize the frequency response of a multilayer miniature FP sensor. An analytical model was derived to describe the effects of a substrate with finite thickness. Finite-element analysis was performed to characterize the temporal response of a sensor with finite dimensions. Miniature 2×2 mm2 FP sensors were designed and fabricated using gold films as reflective mirrors on either side of a parylene C film deposited on a glass wafer. A single-wavelength laser was used to interrogate the sensor using illumination delivered by fiber subprobes. Imaging phantoms were used to verify FP sensor performance, and in vivo images of blood vessels were collected from a live mouse.
UNASSIGNED: The finite thickness substrate of the FP sensor resulted in echoes in the time domain signal that could be removed by back filtering. The substrate acted as a filter in the frequency domain. The finite lateral sensor dimensions produced side waves that could be eliminated by surface averaging using an interrogation beam with adequate diameter. The fabricated FP sensor produced a noise-equivalent pressure = 0.76 kPa, bandwidth of 16.6 MHz, a spectral full-width at-half-maximum = 0.2886 nm, and quality factor Q=2694. Photoacoustic images were collected from phantoms and blood vessels in a live mouse.
UNASSIGNED: A miniature wafer-based FP sensor design has been demonstrated with scaled down form factor for future use in PAE.
摘要：
如果尺寸可以充分按比例缩小,则法布里-珀罗(FP)聚合物膜传感器可以用于检测光声内窥镜(PAE)中的声波。目前的FP传感器在尺寸上有限制，灵敏度,和阵列可配置性。
■我们旨在表征和演示微型FP传感器的成像性能，以评估减小尺寸和有限尺寸的影响。
■开发了传输矩阵模型来表征多层微型FP传感器的频率响应。推导了一个分析模型来描述有限厚度衬底的影响。进行了有限元分析以表征具有有限尺寸的传感器的时间响应。在沉积在玻璃晶片上的聚对二甲苯C膜的任一侧上，使用金膜作为反射镜设计并制造了微型2×2mm2FP传感器。使用单波长激光使用光纤子探针提供的照明来询问传感器。成像体模用于验证FP传感器的性能，从活体小鼠收集血管的体内图像。
■FP传感器的有限厚度衬底导致时域信号中的回波，这些回波可以通过反向滤波去除。衬底在频域中充当滤波器。有限的横向传感器尺寸产生的侧波可以通过使用具有足够直径的询问光束的表面平均来消除。制造的FP传感器产生的噪声等效压力=0.76kPa，带宽为16.6MHz，半最大值处的光谱全宽=0.2886nm，品质因数Q=2694。从活小鼠的体模和血管收集光声图像。
■已经展示了一种基于晶片的微型FP传感器设计，其外形尺寸按比例缩小，可用于PAE。
■我们旨在表征和演示微型FP传感器的成像性能，以评估减小尺寸和有限尺寸的影响。
■开发了传输矩阵模型来表征多层微型FP传感器的频率响应。推导了一个分析模型来描述有限厚度衬底的影响。进行了有限元分析以表征具有有限尺寸的传感器的时间响应。在沉积在玻璃晶片上的聚对二甲苯C膜的任一侧上，使用金膜作为反射镜设计并制造了微型2×2mm2FP传感器。使用单波长激光使用光纤子探针提供的照明来询问传感器。成像体模用于验证FP传感器的性能，从活体小鼠收集血管的体内图像。
■FP传感器的有限厚度衬底导致时域信号中的回波，这些回波可以通过反向滤波去除。衬底在频域中充当滤波器。有限的横向传感器尺寸产生的侧波可以通过使用具有足够直径的询问光束的表面平均来消除。制造的FP传感器产生的噪声等效压力=0.76kPa，带宽为16.6MHz，半最大值处的光谱全宽=0.2886nm，品质因数Q=2694。从活小鼠的体模和血管收集光声图像。
■已经展示了一种基于晶片的微型FP传感器设计，其外形尺寸按比例缩小，可用于PAE。
