PDF(Pubmed)
Abstract：
UNASSIGNED: To explore whether dual-energy computed tomography (DECT) angiography can provide reliable quantitative information on net water uptake (NWU) of ischemic brain to identify stroke patients within 4.5 h.
UNASSIGNED: We retrospectively reviewed 142 patients with stroke occurrence and who underwent DECT angiography between August 2016 and May 2022. DECT angiography manual drawn the ischemic area by referring to the normal area of the contralateral hemisphere and follow-up images. The NWU in the ischemic area was determined using virtual non-contrast and monoenergetic (VNC &VM) images acquired from DECT angiography. The NWU values in the ischemic area were compared between stroke patients within and beyond 4.5 h. The diagnostic performance of the NWU values derived from the VNC and VM images was assessed through receiver operating characteristic curve analysis. Additionally, Furthermore, we examined the correlation between the NWU values and the stroke onset time.
UNASSIGNED: Seventy-eight (54.93 %) stroke patients underwent DECT angiography and within 4.5 h. These patients with lower median National Institute of Health stroke scale (NIHSS) scores on admission than those beyond 4.5 h (p < 0.05). Furthermore, the group within 4.5 h had lower NWU values than did the group beyond 4.5 h on all VNC and VM images (p < 0.001). The analysis revealed that the NWU values determined using the VM (60 keV) images had the highest predictive efficiency (AUC, 0.95; sensitivity, 100 %; and specificity, 89.06 %) and showed the strongest positive correlation with stroke onset time (r-value = 0.58, p < 0.001).
UNASSIGNED: Our findings showed that DECT angiography-based quantification of NWU helps identify the stroke patients within 4.5 h with high predictive efficiency. Thus, NWU values determined using VM (60 keV) images could serve as a significant biomarker for stroke onset time.
UNASSIGNED: We retrospectively reviewed 142 patients with stroke occurrence and who underwent DECT angiography between August 2016 and May 2022. DECT angiography manual drawn the ischemic area by referring to the normal area of the contralateral hemisphere and follow-up images. The NWU in the ischemic area was determined using virtual non-contrast and monoenergetic (VNC &VM) images acquired from DECT angiography. The NWU values in the ischemic area were compared between stroke patients within and beyond 4.5 h. The diagnostic performance of the NWU values derived from the VNC and VM images was assessed through receiver operating characteristic curve analysis. Additionally, Furthermore, we examined the correlation between the NWU values and the stroke onset time.
UNASSIGNED: Seventy-eight (54.93 %) stroke patients underwent DECT angiography and within 4.5 h. These patients with lower median National Institute of Health stroke scale (NIHSS) scores on admission than those beyond 4.5 h (p < 0.05). Furthermore, the group within 4.5 h had lower NWU values than did the group beyond 4.5 h on all VNC and VM images (p < 0.001). The analysis revealed that the NWU values determined using the VM (60 keV) images had the highest predictive efficiency (AUC, 0.95; sensitivity, 100 %; and specificity, 89.06 %) and showed the strongest positive correlation with stroke onset time (r-value = 0.58, p < 0.001).
UNASSIGNED: Our findings showed that DECT angiography-based quantification of NWU helps identify the stroke patients within 4.5 h with high predictive efficiency. Thus, NWU values determined using VM (60 keV) images could serve as a significant biomarker for stroke onset time.
摘要：
■探讨双能计算机断层扫描（DECT）血管造影是否可以提供有关缺血性脑净吸水（NWU）的可靠定量信息，以识别4.5h内的中风患者。
■我们回顾性回顾了2016年8月至2022年5月期间发生卒中并接受DECT血管造影的142例患者。DECT血管造影手册通过参考对侧半球的正常区域和随访图像绘制缺血区域。使用从DECT血管造影获得的虚拟非对比和单能量(VNC&VM)图像确定缺血区域中的NWU。在4.5h内和4.5h后的卒中患者之间比较缺血区域的NWU值。通过受试者工作特征曲线分析评估从VNC和VM图像得出的NWU值的诊断性能。此外,此外，我们检查了NWU值与卒中发病时间之间的相关性.
■78例（54.93％）卒中患者在4.5h内接受了DECT血管造影。这些患者入院时的美国国立卫生研究院卒中量表（NIHSS）评分中位数低于4.5h后的患者（p<0.05）。此外，在所有VNC和VM图像上,4.5h内的组的NWU值低于4.5h后的组(p<0.001).分析显示，使用VM（60keV）图像确定的NWU值具有最高的预测效率（AUC，0.95；灵敏度，100%；和特异性，89.06％），与卒中发作时间呈最强正相关（r值=0.58，p<0.001）。
■我们的发现表明，基于DECT血管造影的NWU定量有助于在4.5h内识别中风患者，具有很高的预测效率。因此，使用VM(60keV)图像确定的NWU值可以用作中风发作时间的重要生物标志物。
■我们回顾性回顾了2016年8月至2022年5月期间发生卒中并接受DECT血管造影的142例患者。DECT血管造影手册通过参考对侧半球的正常区域和随访图像绘制缺血区域。使用从DECT血管造影获得的虚拟非对比和单能量(VNC&VM)图像确定缺血区域中的NWU。在4.5h内和4.5h后的卒中患者之间比较缺血区域的NWU值。通过受试者工作特征曲线分析评估从VNC和VM图像得出的NWU值的诊断性能。此外,此外，我们检查了NWU值与卒中发病时间之间的相关性.
■78例（54.93％）卒中患者在4.5h内接受了DECT血管造影。这些患者入院时的美国国立卫生研究院卒中量表（NIHSS）评分中位数低于4.5h后的患者（p<0.05）。此外，在所有VNC和VM图像上,4.5h内的组的NWU值低于4.5h后的组(p<0.001).分析显示，使用VM（60keV）图像确定的NWU值具有最高的预测效率（AUC，0.95；灵敏度，100%；和特异性，89.06％），与卒中发作时间呈最强正相关（r值=0.58，p<0.001）。
■我们的发现表明，基于DECT血管造影的NWU定量有助于在4.5h内识别中风患者，具有很高的预测效率。因此，使用VM(60keV)图像确定的NWU值可以用作中风发作时间的重要生物标志物。
