PDF(Pubmed)
Abstract：
Brain metastases (BMs) frequently occur in primary tumors such as lung cancer, breast cancer, and melanoma, and are associated with notably short natural survival. In addition to surgical interventions, chemotherapy, targeted therapy, and immunotherapy, radiotherapy (RT) is a crucial treatment for BM and encompasses whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS). Validating the efficacy and safety of treatment regimens through preclinical models is imperative for successful translation to clinical application. This not only advances fundamental research but also forms the theoretical foundation for clinical study. This review, grounded in animal models of brain metastases (AM-BM), explores the theoretical underpinnings and practical applications of radiotherapy in combination with chemotherapy, targeted therapy, immunotherapy, and emerging technologies such as nanomaterials and oxygen-containing microbubbles. Initially, we provided a concise overview of the establishment of AM-BMs. Subsequently, we summarize key RT parameters (RT mode, dose, fraction, dose rate) and their corresponding effects in AM-BMs. Finally, we present a comprehensive analysis of the current research status and future directions for combination therapy based on RT. In summary, there is presently no standardized regimen for AM-BM treatment involving RT. Further research is essential to deepen our understanding of the relationships between various parameters and their respective effects.
摘要：
脑转移（BMs）经常发生在原发性肿瘤如肺癌，乳腺癌,和黑色素瘤，并且与明显短暂的自然生存有关。除了外科手术,化疗,靶向治疗,和免疫疗法，放射治疗（RT）是BM的关键治疗方法，包括全脑放射治疗（WBRT）和立体定向放射外科（SRS）。通过临床前模型验证治疗方案的有效性和安全性对于成功转化为临床应用至关重要。这不仅促进了基础研究，而且为临床研究奠定了理论基础。这次审查,基于脑转移动物模型（AM-BM），探讨放疗联合化疗的理论基础和实际应用，靶向治疗,免疫疗法，以及纳米材料和含氧微泡等新兴技术。最初，我们简要概述了AM-BM的建立。随后，我们总结了关键的RT参数(RT模式，剂量,分数，剂量率)及其在AM-BM中的相应作用。最后，我们对基于RT的联合治疗的研究现状和未来方向进行了全面分析。总之,目前尚无涉及RT的AM-BM治疗的标准化方案。进一步的研究对于加深我们对各种参数及其各自影响之间关系的理解至关重要。
