PDF(Pubmed)
Abstract：
OBJECTIVE: Commercialized total-body PET scanners can provide high-quality images due to its ultra-high sensitivity. We compared the dynamic, regular static, and delayed 18F-fluorodeoxyglucose (FDG) scans to detect lesions in oncologic patients on a total-body PET/CT scanner.
METHODS: In all, 45 patients were scanned continuously for the first 60 min, followed by a delayed acquisition. FDG metabolic rate was calculated from dynamic data using full compartmental modeling, whereas regular static and delayed SUV images were obtained approximately 60- and 145-min post-injection, respectively. The retention index was computed from static and delayed measures for all lesions. Pearson\'s correlation and Kruskal-Wallis tests were used to compare parameters.
RESULTS: The number of lesions was largely identical between the three protocols, except MRFDG and delayed images on total-body PET only detected 4 and 2 more lesions, respectively (85 total). FDG metabolic rate (MRFDG) image-derived contrast-to-noise ratio and target-to-background ratio were significantly higher than those from static standardized uptake value (SUV) images (P < 0.01), but this is not the case for the delayed images (P > 0.05). Dynamic protocol did not significantly differentiate between benign and malignant lesions just like regular SUV, delayed SUV, and retention index.
CONCLUSIONS: The potential quantitative advantages of dynamic imaging may not improve lesion detection and differential diagnosis significantly on a total-body PET/CT scanner. The same conclusion applied to delayed imaging. This suggested the added benefits of complex imaging protocols must be weighed against the complex implementation in the future.
CONCLUSIONS: Total-body PET/CT was known to significantly improve the PET image quality due to its ultra-high sensitivity. However, whether the dynamic and delay imaging on total-body scanner could show additional clinical benefits is largely unknown. Head-to-head comparison between two protocols is relevant to oncological management.
METHODS: In all, 45 patients were scanned continuously for the first 60 min, followed by a delayed acquisition. FDG metabolic rate was calculated from dynamic data using full compartmental modeling, whereas regular static and delayed SUV images were obtained approximately 60- and 145-min post-injection, respectively. The retention index was computed from static and delayed measures for all lesions. Pearson\'s correlation and Kruskal-Wallis tests were used to compare parameters.
RESULTS: The number of lesions was largely identical between the three protocols, except MRFDG and delayed images on total-body PET only detected 4 and 2 more lesions, respectively (85 total). FDG metabolic rate (MRFDG) image-derived contrast-to-noise ratio and target-to-background ratio were significantly higher than those from static standardized uptake value (SUV) images (P < 0.01), but this is not the case for the delayed images (P > 0.05). Dynamic protocol did not significantly differentiate between benign and malignant lesions just like regular SUV, delayed SUV, and retention index.
CONCLUSIONS: The potential quantitative advantages of dynamic imaging may not improve lesion detection and differential diagnosis significantly on a total-body PET/CT scanner. The same conclusion applied to delayed imaging. This suggested the added benefits of complex imaging protocols must be weighed against the complex implementation in the future.
CONCLUSIONS: Total-body PET/CT was known to significantly improve the PET image quality due to its ultra-high sensitivity. However, whether the dynamic and delay imaging on total-body scanner could show additional clinical benefits is largely unknown. Head-to-head comparison between two protocols is relevant to oncological management.
摘要：
目的：商业化的全身PET扫描仪由于具有超高的灵敏度，可以提供高质量的图像。我们比较了动态，常规静态，和延迟18F-氟代脱氧葡萄糖（FDG）扫描以在全身PET/CT扫描仪上检测肿瘤患者的病变。
方法：总之，45例患者连续扫描前60分钟，随后是延迟收购。FDG代谢率是使用完整的隔室建模从动态数据计算的，而常规静态和延迟SUV图像是在注射后大约60和145分钟获得的，分别。保留指数是根据所有病变的静态和延迟测量值计算得出的。使用Pearson相关性和Kruskal-Wallis检验来比较参数。
结果：三种方案的病变数量基本相同，除了MRFDG和全身PET的延迟图像外，仅检测到4个和2个以上的病变，分别（共85个）。FDG代谢率（MRFDG）图像得出的对比噪声比和目标背景比明显高于静态标准化摄取值（SUV）图像（P<0.01）。但这不是延迟图像的情况（P>0.05）。动态协议没有像普通SUV一样显著区分良性和恶性病变，延迟的SUV,和保留指数。
结论：动态成像的潜在定量优势可能无法显著改善全身PET/CT扫描仪的病变检测和鉴别诊断。同样的结论适用于延迟成像。这表明必须在将来权衡复杂成像协议的附加好处。
结论：已知全身PET/CT由于其超高灵敏度而显着改善PET图像质量。然而,全身扫描仪上的动态成像和延迟成像是否能显示额外的临床获益在很大程度上是未知的.两种方案之间的头对头比较与肿瘤管理有关。
方法：总之，45例患者连续扫描前60分钟，随后是延迟收购。FDG代谢率是使用完整的隔室建模从动态数据计算的，而常规静态和延迟SUV图像是在注射后大约60和145分钟获得的，分别。保留指数是根据所有病变的静态和延迟测量值计算得出的。使用Pearson相关性和Kruskal-Wallis检验来比较参数。
结果：三种方案的病变数量基本相同，除了MRFDG和全身PET的延迟图像外，仅检测到4个和2个以上的病变，分别（共85个）。FDG代谢率（MRFDG）图像得出的对比噪声比和目标背景比明显高于静态标准化摄取值（SUV）图像（P<0.01）。但这不是延迟图像的情况（P>0.05）。动态协议没有像普通SUV一样显著区分良性和恶性病变，延迟的SUV,和保留指数。
结论：动态成像的潜在定量优势可能无法显著改善全身PET/CT扫描仪的病变检测和鉴别诊断。同样的结论适用于延迟成像。这表明必须在将来权衡复杂成像协议的附加好处。
结论：已知全身PET/CT由于其超高灵敏度而显着改善PET图像质量。然而,全身扫描仪上的动态成像和延迟成像是否能显示额外的临床获益在很大程度上是未知的.两种方案之间的头对头比较与肿瘤管理有关。
