Abstract：
To provide a comprehensive account of the association of MMP-9 gene polymorphisms (rs3918242) with susceptibility to cancer. A literature search for eligible candidate gene studies published before May 27, 2022 was conducted in PubMed, Medline, Google Scholar and Web of Science. Potential sources of heterogeneity were sought out across subgroups and sensitivity analysis. Publication bias were also estimated. Overall, a total of 37 articles with 7616 cases and 8165 controls for rs3918242 gene polymorphisms were enrolled. Our meta-analysis suggests that MMP-9 rs3918242 might be associated with breast cancer and gastric cancer susceptibility, and perhaps reduce the risk of lung cancer.
摘要：
目的全面介绍MMP-9基因多态性(rs3918242)与癌症易感性的关系。在PubMed上对2022年5月27日之前发表的合格候选基因研究进行了文献检索，Medline,谷歌学者和WebofScience。在亚组和敏感性分析中寻找异质性的潜在来源。还估计了出版偏倚。总的来说,共纳入37篇文献，7616例，8165例rs3918242基因多态性对照。我们的荟萃分析表明MMP-9rs3918242可能与乳腺癌和胃癌的易感性有关。并可能降低患肺癌的风险。
