Abstract：
Macular amyloidosis (MA) is one of the most common types of primary localized cutaneous amyloidosis (PLCA), distributed predominantly over the trunk and extremities. Due to the vast therapeutic options, this study aims to compare the effectiveness of Q-switched Nd: YAG laser 1064 nm and Er: YAG laser 2940 nm in treating MA. This clinical trial was performed in 2020-2021 on 33 women with MA. In each patient, the lesion was randomly divided into two areas, A and B. Area A underwent four treatment sessions with 4-week intervals of Q-switched Nd: YAG laser 1064 nm. Area B underwent four treatment sessions with an Er: YAG laser 2940 nm at 4-week intervals. Degree of basal pigmentation and degree of pigmentation after treatment, pruritus intensity, before and after the treatment, and patient and physicians\' satisfaction were measured and compared. The pruritus in patients improved significantly after the study (P < 0.001), but no significant differences could be observed between the two groups regarding the improvements (P > 0.05). We also found no significant differences between the two groups of patients regarding patient and physicians\' satisfaction rates (P > 0.05). The use of both Q-switched Nd: YAG laser and Er: YAG laser resulted in improvements in terms of pruritus, patient and physicians\' satisfaction, and total improvement in pigmentation of the lesions.
摘要：
黄斑淀粉样变性（MA）是原发性局限性皮肤淀粉样变性（PLCA）的最常见类型之一，主要分布在躯干和四肢。由于广泛的治疗选择，本研究旨在比较1064nm调QNd：YAG激光和2940nmEr：YAG激光治疗MA的有效性。这项临床试验于2020-2021年对33名患有MA的女性进行。在每个病人中,病变被随机分为两个区域，A和B.A区进行了4个疗程，间隔4周的Q开关Nd：YAG激光1064nm。区域B以4周的间隔用Er:YAG激光器2940nm进行四次治疗。基础色素沉着程度及治疗后色素沉着程度,瘙痒强度,治疗前后,对患者和医生的满意度进行了测量和比较。研究后患者瘙痒症状明显改善(P<0.001),但两组之间在改善方面没有显着差异（P>0.05）。我们还发现两组患者在患者和医师满意度方面没有显着差异（P>0.05）。Q开关Nd：YAG激光和Er：YAG激光的使用导致瘙痒方面的改善，病人和医生的满意度，和完全改善病变的色素沉着。
