PDF(Pubmed)
Abstract：
UNASSIGNED: Escherichia coli and Klebsiella pneumoniae are prevalent Gram-negative microorganisms responsible for pneumonia, as well as the primary Enterobacteriaceae pathogens causing bacteremic pneumonia. The objective of this research is to analyze the risk factors associated with bacteremic pneumonia caused by these pathogens and develop a predictive model.
UNASSIGNED: This retrospective investigation encompassed a cohort of 252 patients diagnosed with Escherichia coli or Klebsiella pneumoniae-induced bacteremic pneumonia between 2018 and 2022. The primary endpoint was 30-day mortality, which was analyzed using multifactorial logistic regression, nomogram construction, and Bootstrap validation.
UNASSIGNED: Among the 252 patients diagnosed with Escherichia coli and Klebsiella pneumoniae, 65 succumbed to the disease while 187 survived. The overall 30-day mortality was found to be 25.8%. A multifactorial logistic regression analysis revealed that diastolic blood pressure, cerebrovascular diseases/transient ischemic attacks (TIA), immunosuppression, blood urea nitrogen, Pitt score, and CURB-65 score were statistically significant factors. The Nomogram model demonstrated an AUC of 0.954, which closely aligns with the Bootstrap-derived mean AUC of 0.953 (95% CI: 0.952-0.954).
UNASSIGNED: In patients with bacteremic pneumonia caused by Escherichia coli and Klebsiella pneumoniae, Low diastolic blood pressure (≤61 mmHg), pre-existing cerebrovascular disease/ transient ischemic attacks (TIA), immunosuppression status, elevated blood urea nitrogen levels (≥8.39 mmol/L), high Pitt score (≥3), and a high CURB-65 score (≥2) are all independent risk factors for Escherichia coli and Klebsiella pneumoniae bacteremic pneumonia, among which the first three warrant particular attention.
UNASSIGNED: This retrospective investigation encompassed a cohort of 252 patients diagnosed with Escherichia coli or Klebsiella pneumoniae-induced bacteremic pneumonia between 2018 and 2022. The primary endpoint was 30-day mortality, which was analyzed using multifactorial logistic regression, nomogram construction, and Bootstrap validation.
UNASSIGNED: Among the 252 patients diagnosed with Escherichia coli and Klebsiella pneumoniae, 65 succumbed to the disease while 187 survived. The overall 30-day mortality was found to be 25.8%. A multifactorial logistic regression analysis revealed that diastolic blood pressure, cerebrovascular diseases/transient ischemic attacks (TIA), immunosuppression, blood urea nitrogen, Pitt score, and CURB-65 score were statistically significant factors. The Nomogram model demonstrated an AUC of 0.954, which closely aligns with the Bootstrap-derived mean AUC of 0.953 (95% CI: 0.952-0.954).
UNASSIGNED: In patients with bacteremic pneumonia caused by Escherichia coli and Klebsiella pneumoniae, Low diastolic blood pressure (≤61 mmHg), pre-existing cerebrovascular disease/ transient ischemic attacks (TIA), immunosuppression status, elevated blood urea nitrogen levels (≥8.39 mmol/L), high Pitt score (≥3), and a high CURB-65 score (≥2) are all independent risk factors for Escherichia coli and Klebsiella pneumoniae bacteremic pneumonia, among which the first three warrant particular attention.
摘要：
■大肠杆菌和肺炎克雷伯菌是导致肺炎的常见革兰氏阴性微生物，以及引起细菌性肺炎的主要肠杆菌科病原体。这项研究的目的是分析与这些病原体引起的菌血症肺炎相关的危险因素，并建立预测模型。
■这项回顾性调查涵盖了在2018年至2022年间诊断为大肠杆菌或肺炎克雷伯菌引起的菌血症肺炎的252例患者。主要终点是30天死亡率，使用多因素逻辑回归分析，列线图构造，和Bootstrap验证。
■在被诊断为大肠杆菌和肺炎克雷伯菌的252名患者中，65人死于该疾病，而187人幸存。总的30天死亡率为25.8%。多因素logistic回归分析显示，舒张压，脑血管疾病/短暂性脑缺血发作（TIA），免疫抑制,血尿素氮,皮特得分,和CURB-65评分是有统计学意义的因素。列线图模型显示的AUC为0.954，与Bootstrap衍生的平均AUC为0.953（95％CI：0.952-0.954）密切相关。
■在由大肠杆菌和肺炎克雷伯菌引起的菌血症肺炎患者中，低舒张压（≤61mmHg），预先存在的脑血管疾病/短暂性脑缺血发作（TIA），免疫抑制状态，血尿素氮水平升高（≥8.39mmol/L），高Pitt评分（≥3），高CURB-65评分（≥2）是大肠埃希菌和肺炎克雷伯菌菌血症肺炎的独立危险因素，其中前三个值得特别关注。
■这项回顾性调查涵盖了在2018年至2022年间诊断为大肠杆菌或肺炎克雷伯菌引起的菌血症肺炎的252例患者。主要终点是30天死亡率，使用多因素逻辑回归分析，列线图构造，和Bootstrap验证。
■在被诊断为大肠杆菌和肺炎克雷伯菌的252名患者中，65人死于该疾病，而187人幸存。总的30天死亡率为25.8%。多因素logistic回归分析显示，舒张压，脑血管疾病/短暂性脑缺血发作（TIA），免疫抑制,血尿素氮,皮特得分,和CURB-65评分是有统计学意义的因素。列线图模型显示的AUC为0.954，与Bootstrap衍生的平均AUC为0.953（95％CI：0.952-0.954）密切相关。
■在由大肠杆菌和肺炎克雷伯菌引起的菌血症肺炎患者中，低舒张压（≤61mmHg），预先存在的脑血管疾病/短暂性脑缺血发作（TIA），免疫抑制状态，血尿素氮水平升高（≥8.39mmol/L），高Pitt评分（≥3），高CURB-65评分（≥2）是大肠埃希菌和肺炎克雷伯菌菌血症肺炎的独立危险因素，其中前三个值得特别关注。
