UNASSIGNED: This retrospective investigation encompassed a cohort of 252 patients diagnosed with Escherichia coli or Klebsiella pneumoniae-induced bacteremic pneumonia between 2018 and 2022. The primary endpoint was 30-day mortality, which was analyzed using multifactorial logistic regression, nomogram construction, and Bootstrap validation.
UNASSIGNED: Among the 252 patients diagnosed with Escherichia coli and Klebsiella pneumoniae, 65 succumbed to the disease while 187 survived. The overall 30-day mortality was found to be 25.8%. A multifactorial logistic regression analysis revealed that diastolic blood pressure, cerebrovascular diseases/transient ischemic attacks (TIA), immunosuppression, blood urea nitrogen, Pitt score, and CURB-65 score were statistically significant factors. The Nomogram model demonstrated an AUC of 0.954, which closely aligns with the Bootstrap-derived mean AUC of 0.953 (95% CI: 0.952-0.954).
UNASSIGNED: In patients with bacteremic pneumonia caused by Escherichia coli and Klebsiella pneumoniae, Low diastolic blood pressure (≤61 mmHg), pre-existing cerebrovascular disease/ transient ischemic attacks (TIA), immunosuppression status, elevated blood urea nitrogen levels (≥8.39 mmol/L), high Pitt score (≥3), and a high CURB-65 score (≥2) are all independent risk factors for Escherichia coli and Klebsiella pneumoniae bacteremic pneumonia, among which the first three warrant particular attention.
■这项回顾性调查涵盖了在2018年至2022年间诊断为大肠杆菌或肺炎克雷伯菌引起的菌血症肺炎的252例患者。主要终点是30天死亡率,使用多因素逻辑回归分析,列线图构造,和Bootstrap验证。
■在被诊断为大肠杆菌和肺炎克雷伯菌的252名患者中,65人死于该疾病,而187人幸存。总的30天死亡率为25.8%。多因素logistic回归分析显示,舒张压,脑血管疾病/短暂性脑缺血发作(TIA),免疫抑制,血尿素氮,皮特得分,和CURB-65评分是有统计学意义的因素。列线图模型显示的AUC为0.954,与Bootstrap衍生的平均AUC为0.953(95%CI:0.952-0.954)密切相关。
■在由大肠杆菌和肺炎克雷伯菌引起的菌血症肺炎患者中,低舒张压(≤61mmHg),预先存在的脑血管疾病/短暂性脑缺血发作(TIA),免疫抑制状态,血尿素氮水平升高(≥8.39mmol/L),高Pitt评分(≥3),高CURB-65评分(≥2)是大肠埃希菌和肺炎克雷伯菌菌血症肺炎的独立危险因素,其中前三个值得特别关注。