PDF(Pubmed)
Abstract：
UNASSIGNED: Cell-free fetal DNA (cffDNA) is a novel screening method for fetal aneuploidy that facilitated non-invasive prenatal testing (NIPT) through analysis of cffDNA in maternal plasma. However, despite increased sensitivity, it has a number of limitations that may complicate of its results interpretation. Therefore, elucidating factors affecting fetal fraction, as a critical limitation, guides its clinical application.
UNASSIGNED: In this report, systematic search was carried out through PubMed, Web of Science, and Scopus databases until February 11, 2022 by using keywords consist of \"noninvasive prenatal screening\", \"NIPT\", \"noninvasive prenatal\", \"cell free DNA\" and \"fetal fraction\". The articles were screened for eligibility criteria before data extraction.
UNASSIGNED: A total of 39 eligible studies, most published between 2010 and 2020, were included. Based on the results of studies, a negative correlation between maternal age and BMI/body weight with fetal fraction was found. Furthermore, LDL, cholesterol, triglyceride level, metformin, heparin and enoxaparin therapy, hemoglobin-related hemoglobinopathies, and physical activity showed to have negative associations. Interestingly, it seems the ethnicity of patients from South and East Asia has a correlation with fetal fraction compared to Caucasians. Positive correlation was observed between gestational age, free β-hCG, PAPP-A, living in high altitude, and twin pregnancy.
UNASSIGNED: Considering each factor, there was significant inconsistency and controversy regarding their impact on outcomes. Indeed, multiple factors can influence the accuracy of NIPS results, and it is worth noting that the impact of these factors may vary depending on the individual\'s ethnic background. Therefore, it is important to recognize that NIPS remains a screening test, and comprehensive pre- and post-NIPS counseling should be conducted as part of standard clinical practice.
UNASSIGNED: In this report, systematic search was carried out through PubMed, Web of Science, and Scopus databases until February 11, 2022 by using keywords consist of \"noninvasive prenatal screening\", \"NIPT\", \"noninvasive prenatal\", \"cell free DNA\" and \"fetal fraction\". The articles were screened for eligibility criteria before data extraction.
UNASSIGNED: A total of 39 eligible studies, most published between 2010 and 2020, were included. Based on the results of studies, a negative correlation between maternal age and BMI/body weight with fetal fraction was found. Furthermore, LDL, cholesterol, triglyceride level, metformin, heparin and enoxaparin therapy, hemoglobin-related hemoglobinopathies, and physical activity showed to have negative associations. Interestingly, it seems the ethnicity of patients from South and East Asia has a correlation with fetal fraction compared to Caucasians. Positive correlation was observed between gestational age, free β-hCG, PAPP-A, living in high altitude, and twin pregnancy.
UNASSIGNED: Considering each factor, there was significant inconsistency and controversy regarding their impact on outcomes. Indeed, multiple factors can influence the accuracy of NIPS results, and it is worth noting that the impact of these factors may vary depending on the individual\'s ethnic background. Therefore, it is important to recognize that NIPS remains a screening test, and comprehensive pre- and post-NIPS counseling should be conducted as part of standard clinical practice.
摘要：
■无细胞胎儿DNA（cffDNA）是一种新颖的胎儿非整倍性筛查方法，可通过分析母体血浆中的cffDNA来促进非侵入性产前检测（NIPT）。然而,尽管灵敏度提高了，它有许多限制，可能会使其结果解释复杂化。因此,阐明影响胎儿分数的因素，作为一个关键的限制，指导其临床应用。
■在本报告中，通过PubMed进行了系统搜索，WebofScience,和Scopus数据库，直到2022年2月11日，通过使用关键词组成的“无创产前筛查”，\"NIPT\",\“无创产前\”，“无细胞DNA”和“胎儿分数”。在数据提取之前，对文章进行资格标准筛选。
■共39项符合条件的研究，大多数在2010年至2020年期间出版的，都包括在内。根据研究结果,发现孕妇年龄和BMI/体重与胎儿分数呈负相关.此外，LDL,胆固醇,甘油三酯水平，二甲双胍,肝素和依诺肝素治疗，血红蛋白相关血红蛋白病,和身体活动表现出负相关。有趣的是,与高加索人相比,南亚和东亚患者的种族似乎与胎儿分数相关.胎龄之间呈正相关，游离β-hCG,PAPP-A,生活在高海拔地区,双胞胎怀孕。
■考虑到每个因素，它们对结局的影响存在显著的不一致和争议.的确,多种因素会影响NIPS结果的准确性，值得注意的是，这些因素的影响可能因个人的种族背景而异。因此,重要的是要认识到NIPS仍然是一种筛查测试，NIPS前后的全面咨询应作为标准临床实践的一部分进行。
■在本报告中，通过PubMed进行了系统搜索，WebofScience,和Scopus数据库，直到2022年2月11日，通过使用关键词组成的“无创产前筛查”，\"NIPT\",\“无创产前\”，“无细胞DNA”和“胎儿分数”。在数据提取之前，对文章进行资格标准筛选。
■共39项符合条件的研究，大多数在2010年至2020年期间出版的，都包括在内。根据研究结果,发现孕妇年龄和BMI/体重与胎儿分数呈负相关.此外，LDL,胆固醇,甘油三酯水平，二甲双胍,肝素和依诺肝素治疗，血红蛋白相关血红蛋白病,和身体活动表现出负相关。有趣的是,与高加索人相比,南亚和东亚患者的种族似乎与胎儿分数相关.胎龄之间呈正相关，游离β-hCG,PAPP-A,生活在高海拔地区,双胞胎怀孕。
■考虑到每个因素，它们对结局的影响存在显著的不一致和争议.的确,多种因素会影响NIPS结果的准确性，值得注意的是，这些因素的影响可能因个人的种族背景而异。因此,重要的是要认识到NIPS仍然是一种筛查测试，NIPS前后的全面咨询应作为标准临床实践的一部分进行。
