Abstract：
BACKGROUND: Alzheimer\'s disease (AD) is highly intertwined with sleep disturbances throughout its whole natural history. Sleep consists of a major compound of the functionality of the glymphatic system, as the synchronized slow-wave activity during NREM facilitates cerebrospinal and interstitial long-distance mixing.
OBJECTIVE: The present study undertakes a scoping review of research on the involvement of the glymphatic system in AD-related sleep disturbances.
METHODS: we searched Medline, Embase, PsychInfo and HEAL-link databases, without limitations on date and language, along with reference lists of relevant reviews and all included studies. We included in vivo, in vitro and post-mortem studies examining glymphatic implications of sleep disturbances in human populations with AD spectrum pathology. A thematic synthesis of evidence based on the extracted content was applied and presented in a narrative way.
RESULTS: In total, 70 original research articles were included and were grouped as following: a) Protein aggregation and toxicity, after sleep deprivation, along with its effects on sleep architecture, b) Glymphatic Sequalae in SDB, yielding potential glymphatic markers c) Circadian Dysregulation, d) Possible Interventions.
CONCLUSIONS: this review sought to provide insight into the role of sleep disturbances in AD pathogenesis, in the context of the glymphatic disruption.
OBJECTIVE: The present study undertakes a scoping review of research on the involvement of the glymphatic system in AD-related sleep disturbances.
METHODS: we searched Medline, Embase, PsychInfo and HEAL-link databases, without limitations on date and language, along with reference lists of relevant reviews and all included studies. We included in vivo, in vitro and post-mortem studies examining glymphatic implications of sleep disturbances in human populations with AD spectrum pathology. A thematic synthesis of evidence based on the extracted content was applied and presented in a narrative way.
RESULTS: In total, 70 original research articles were included and were grouped as following: a) Protein aggregation and toxicity, after sleep deprivation, along with its effects on sleep architecture, b) Glymphatic Sequalae in SDB, yielding potential glymphatic markers c) Circadian Dysregulation, d) Possible Interventions.
CONCLUSIONS: this review sought to provide insight into the role of sleep disturbances in AD pathogenesis, in the context of the glymphatic disruption.
摘要：
背景：阿尔茨海默病（AD）在其整个自然史上与睡眠障碍高度交织在一起。睡眠由淋巴系统功能的主要化合物组成，因为NREM期间同步的慢波活动促进了脑脊液和间质的长距离混合。
目的：本研究对类淋巴系统参与AD相关睡眠障碍的研究进行了范围综述。
方法：我们搜索了Medline，Embase,PsychInfo和HEAL链接数据库，没有日期和语言的限制，以及相关综述和所有纳入研究的参考列表。我们包括在体内，体外和验尸研究，检查了患有AD频谱病理的人群中睡眠障碍的淋巴意义。应用了基于提取内容的证据主题综合，并以叙事方式呈现。
结果：总计，包括70篇原始研究文章，并分组如下：a)蛋白质聚集和毒性，剥夺睡眠后，以及它对睡眠结构的影响，b)SDB中的淋巴后遗症,产生潜在的淋巴标记c）昼夜节律失调，d)可能的干预措施。
结论：这篇综述旨在深入了解睡眠障碍在AD发病机制中的作用。在淋巴淋巴破坏的背景下。
目的：本研究对类淋巴系统参与AD相关睡眠障碍的研究进行了范围综述。
方法：我们搜索了Medline，Embase,PsychInfo和HEAL链接数据库，没有日期和语言的限制，以及相关综述和所有纳入研究的参考列表。我们包括在体内，体外和验尸研究，检查了患有AD频谱病理的人群中睡眠障碍的淋巴意义。应用了基于提取内容的证据主题综合，并以叙事方式呈现。
结果：总计，包括70篇原始研究文章，并分组如下：a)蛋白质聚集和毒性，剥夺睡眠后，以及它对睡眠结构的影响，b)SDB中的淋巴后遗症,产生潜在的淋巴标记c）昼夜节律失调，d)可能的干预措施。
结论：这篇综述旨在深入了解睡眠障碍在AD发病机制中的作用。在淋巴淋巴破坏的背景下。
