{Reference Type}: Review
{Title}: Sleep disorders and Alzheimer's disease pathophysiology: The role of the Glymphatic System. A scoping review.
{Author}: Astara K;Tsimpolis A;Kalafatakis K;Vavougios GD;Xiromerisiou G;Dardiotis E;Christodoulou NG;Samara MT;Lappas AS;
{Journal}: Mech Ageing Dev
{Volume}: 217
{Issue}: 0
{Year}: 2024 Feb 30
{Factor}: 5.498
{DOI}: 10.1016/j.mad.2023.111899
{Abstract}: <B>BACKGROUND: </B>Alzheimer's disease (AD) is highly intertwined with sleep disturbances throughout its whole natural history. Sleep consists of a major compound of the functionality of the glymphatic system, as the synchronized slow-wave activity during NREM facilitates cerebrospinal and interstitial long-distance mixing.<BR><B>OBJECTIVE: </B>The present study undertakes a scoping review of research on the involvement of the glymphatic system in AD-related sleep disturbances.<BR><B>METHODS: </B>we searched Medline, Embase, PsychInfo and HEAL-link databases, without limitations on date and language, along with reference lists of relevant reviews and all included studies. We included in vivo, in vitro and post-mortem studies examining glymphatic implications of sleep disturbances in human populations with AD spectrum pathology. A thematic synthesis of evidence based on the extracted content was applied and presented in a narrative way.<BR><B>RESULTS: </B>In total, 70 original research articles were included and were grouped as following: a) Protein aggregation and toxicity, after sleep deprivation, along with its effects on sleep architecture, b) Glymphatic Sequalae in SDB, yielding potential glymphatic markers c) Circadian Dysregulation, d) Possible Interventions.<BR><B>CONCLUSIONS: </B>this review sought to provide insight into the role of sleep disturbances in AD pathogenesis, in the context of the glymphatic disruption.