PDF(Pubmed)
Abstract：
The utilization of negative pressure wound therapy (NPWT) in lowering the incidence of infections in closed colorectal surgical incisions has not been thoroughly established, and recent trials have had conflicting results. This meta-analysis was conducted to synthesize the findings of available trial data and carefully evaluate the effectiveness of this intervention in colorectal surgery. The databases PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were combed for randomized controlled trials (RCTs) that compared negative pressure wound therapy to standard dressing in closed wounds of patients undergoing colorectal surgery. The incidence of surgical site infections (SSIs) was the primary outcome. Secondary outcomes included the occurrence of seroma and hematoma. The trial results were represented as odds ratios (OR) with a 95% confidence interval (CI), and a fixed-effects model was used. Nine studies found eligible were included, and the pooled results revealed that negative pressure wound therapy significantly reduced the incidence of surgical site infections (OR: 0.70; 95% CI: 0.53, 0.93; P= 0.02). Furthermore, there was a significant reduction in seroma (OR: 0.27; 95% CI: 0.08, 0.95; P = 0.04) and hematoma (OR: 0.20; 95% CI: 0.04, 0.96; P = 0.04). The use of negative pressure wound therapy for primarily closed incisions has been increasing, and our results indicate that it is superior to standard surgical dressings in preventing surgical site infections and other wound complications in colorectal surgeries.
摘要：
使用负压伤口治疗（NPWT）降低闭合性结直肠手术切口感染的发生率尚未完全确定。最近的试验结果相互矛盾。进行这项荟萃分析是为了综合现有试验数据的发现，并仔细评估这种干预措施在结直肠手术中的有效性。数据库PubMed,Embase,和Cochrane中央对照试验注册中心(CENTRAL)进行了随机对照试验(RCT),比较了接受结直肠手术的患者的闭合伤口中的负压伤口治疗与标准敷料.手术部位感染（SSIs）的发生率是主要结果。次要结果包括血清肿和血肿的发生。试验结果以比值比(OR)表示，置信区间为95%，并使用固定效应模型。纳入了九项符合条件的研究，合并结果显示,负压伤口治疗显著降低了手术部位感染的发生率(OR:0.70;95%CI:0.53,0.93;P=0.02).此外，血清肿(OR:0.27;95%CI:0.08,0.95;P=0.04)和血肿(OR:0.20;95%CI:0.04,0.96;P=0.04)均显著减少.主要用于闭合切口的负压伤口治疗的使用一直在增加，我们的结果表明，在预防结直肠手术中手术部位感染和其他伤口并发症方面，它优于标准外科敷料。
