Abstract：
OBJECTIVE: circumvallate placenta, placental abruption and acute chorioamnionitis separately are associated with unfavourable clinical outcomes. We aimed to determine the prevalence and define whether an association exists between the three abnormalities.
METHODS: 16,042 placenta pathology reports between 1997 and 2020 from a tertiary care centre in the Netherlands were retrospectively analysed. For the statistical analysis, the chi-square test and bootstrapping were used to evaluate an association.
RESULTS: In our cohort the prevalence of circumvallate placenta is 2.2 %, placental abruption cases 4.0 % and acute chorioamnionitis 20.6 %. We observed a statistically significant association between all three placental abnormalities: circumvallate placenta, placental abruption and acute chorioamnionitis. In addition, there was also an association between circumvallate placenta and acute chorioamnionitis.
CONCLUSIONS: Our results show that combined presence of circumvallate placenta, placental abruption and acute chorioamnionitis are associated in preterm birth (p = 0.001). A remarkable finding is that the combination of all three abnormalities (circumvallate placenta, placental abruption and acute chorioamnionitis) was not observed in term pregnancies >37 weeks.
METHODS: 16,042 placenta pathology reports between 1997 and 2020 from a tertiary care centre in the Netherlands were retrospectively analysed. For the statistical analysis, the chi-square test and bootstrapping were used to evaluate an association.
RESULTS: In our cohort the prevalence of circumvallate placenta is 2.2 %, placental abruption cases 4.0 % and acute chorioamnionitis 20.6 %. We observed a statistically significant association between all three placental abnormalities: circumvallate placenta, placental abruption and acute chorioamnionitis. In addition, there was also an association between circumvallate placenta and acute chorioamnionitis.
CONCLUSIONS: Our results show that combined presence of circumvallate placenta, placental abruption and acute chorioamnionitis are associated in preterm birth (p = 0.001). A remarkable finding is that the combination of all three abnormalities (circumvallate placenta, placental abruption and acute chorioamnionitis) was not observed in term pregnancies >37 weeks.
摘要：
目标：环绕胎盘，胎盘早剥和急性绒毛膜羊膜炎分别与不利的临床结局相关。我们旨在确定患病率，并确定这三种异常之间是否存在关联。
方法：回顾性分析了1997年至2020年间荷兰三级护理中心的16,042例胎盘病理报告。对于统计分析，卡方检验和自举试验用于评估相关性.
结果：在我们的队列中，环状胎盘的患病率为2.2％，胎盘早剥4.0%,急性绒毛膜羊膜炎20.6%。我们观察到所有三种胎盘异常之间的统计学显着关联：周围胎盘，胎盘早剥和急性绒毛膜羊膜炎。此外,周围胎盘和急性绒毛膜羊膜炎之间也有关联.
结论：我们的结果表明，合并存在包绕胎盘，胎盘早剥和急性绒毛膜羊膜炎与早产相关（p=0.001）。一个显著的发现是，所有三种异常的组合(周围胎盘，在足月妊娠>37周未观察到胎盘早剥和急性绒毛膜羊膜炎）。
方法：回顾性分析了1997年至2020年间荷兰三级护理中心的16,042例胎盘病理报告。对于统计分析，卡方检验和自举试验用于评估相关性.
结果：在我们的队列中，环状胎盘的患病率为2.2％，胎盘早剥4.0%,急性绒毛膜羊膜炎20.6%。我们观察到所有三种胎盘异常之间的统计学显着关联：周围胎盘，胎盘早剥和急性绒毛膜羊膜炎。此外,周围胎盘和急性绒毛膜羊膜炎之间也有关联.
结论：我们的结果表明，合并存在包绕胎盘，胎盘早剥和急性绒毛膜羊膜炎与早产相关（p=0.001）。一个显著的发现是，所有三种异常的组合(周围胎盘，在足月妊娠>37周未观察到胎盘早剥和急性绒毛膜羊膜炎）。
