{Reference Type}: Journal Article
{Title}: Significant association between circumvallate placenta, placental abruption and acute chorioamnionitis in preterm birth: A 23-year retrospective cohort study.
{Author}: Stuijt DG;Bos M;Nikkels PGJ;Wolterbeek R;van der Meeren LE;
{Journal}: Placenta
{Volume}: 146
{Issue}: 0
{Year}: 2024 Feb 27
{Factor}: 3.287
{DOI}: 10.1016/j.placenta.2023.12.018
{Abstract}: <B>OBJECTIVE: </B>circumvallate placenta, placental abruption and acute chorioamnionitis separately are associated with unfavourable clinical outcomes. We aimed to determine the prevalence and define whether an association exists between the three abnormalities.<BR><B>METHODS: </B>16,042 placenta pathology reports between 1997 and 2020 from a tertiary care centre in the Netherlands were retrospectively analysed. For the statistical analysis, the chi-square test and bootstrapping were used to evaluate an association.<BR><B>RESULTS: </B>In our cohort the prevalence of circumvallate placenta is 2.2 %, placental abruption cases 4.0 % and acute chorioamnionitis 20.6 %. We observed a statistically significant association between all three placental abnormalities: circumvallate placenta, placental abruption and acute chorioamnionitis. In addition, there was also an association between circumvallate placenta and acute chorioamnionitis.<BR><B>CONCLUSIONS: </B>Our results show that combined presence of circumvallate placenta, placental abruption and acute chorioamnionitis are associated in preterm birth (p = 0.001). A remarkable finding is that the combination of all three abnormalities (circumvallate placenta, placental abruption and acute chorioamnionitis) was not observed in term pregnancies >37 weeks.