PDF(Pubmed)
Abstract：
The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following abdominal surgery in rat model of postoperative ileus. Bowel motility was measured by the intestinal transit of Evans blue introduced via orogastric tube after surgical procedures of skin incision, laparotomy and laparotomy with gut manipulation. Male rats were given individual adrenergic receptor subtypes antagonists intraperitoneally, and the influence of administered agents on intestinal transit of Evans blue was then evaluated. No statistically significant differences in the length of intestine in tested rats were observed. Propranolol administered prior to surgical procedure has shown protective effect on Evans blue migration in rats undergoing laparotomy and gut manipulation. Intestinal dye transit for propranolol doses of 10, 30 and 45 mg/kg was 18.00 ± 1.88c m, 23.75 ± 1.71 cm and 22.5 ± 2.43 cm, respectively, and for last two doses, statistically significant increase of dye passage was noted, compared to Evans blue transit of 11.00 ± 2.43 cm in the control group. No acceleration of dye migration was seen following administration of beta1-, beta2- and beta3-selective adrenergic receptor antagonist metoprolol, ICI 118.551 and SR58894A, respectively. Our research confirmed that propranolol at high doses, as seen by other researchers, improved bowel motility in early phase of postoperative ileus. That slight acceleration of intestinal dye transit after surgery with gut manipulation is rather connected with membrane-stabilizing action, than the receptor blocking effect, as this effect was not observed after the application of selective antagonists of respective subtypes of beta-adrenergic receptor.
摘要：
研究的目的是评估特定β-肾上腺素能受体亚型拮抗剂对大鼠术后肠梗阻模型腹部手术后肠动力的影响。通过皮肤切开手术后通过口胃管引入的伊文思蓝的肠道运输来测量肠道蠕动，开腹手术和开腹手术。雄性大鼠腹膜内给予个体肾上腺素能受体亚型拮抗剂，然后评估给药药物对伊文思蓝肠道运输的影响。在测试的大鼠中没有观察到肠长度的统计学显著差异。手术前给予普萘洛尔对剖腹手术和肠道操作大鼠的伊文思蓝迁移具有保护作用。普萘洛尔剂量为10、30和45mg/kg的肠道染料转运为18.00±1.88cm，23.75±1.71厘米和22.5±2.43厘米，分别,最后两剂，注意到染料通道的统计学显着增加，对照组为11.00±2.43cm的伊文思蓝过境。施用β1-后未发现染料迁移加速，β2-和β3-选择性肾上腺素能受体拮抗剂美托洛尔，ICI118.551和SR58894A，分别。我们的研究证实高剂量的普萘洛尔,正如其他研究人员看到的那样，改善术后肠梗阻早期的肠动力。肠道操作手术后肠道染料运输的轻微加速与膜稳定作用有关，而不是受体阻断作用，因为在应用各自亚型的β-肾上腺素能受体的选择性拮抗剂后未观察到这种作用。
