Abstract：
UNASSIGNED: Lepidium sativum, Garden Cress (GC), seeds have a lot of natural molecules with a pronounced activity against different disorders. It was reported that GC seeds have the ability to lower the blood glucose level.
UNASSIGNED: The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin rats\' model in comparison with positive control metformin.
UNASSIGNED: Micrometrics of GC grounded seeds with different excipients were investigated. Then, GC tablets were prepared via direct compression technique. GC tablets were characterized for their uniformity of dosage unit, friability, hardness, disintegration time, and in vitro release. The antidiabetic effect was studied in rats for a period of 28 days. Glycosylated hemoglobin, liver performance, and lipid levels include total cholesterol (TC), triglycerides (TGs), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also estimated. In addition, histopathological study of liver and pancreas was also performed.
UNASSIGNED: Prosolv®EasyTab produced tablets with higher hardness, lower disintegration time, and fast release. GC tablets significantly lower the elevated blood glucose level. In addition, they have antihyperlipidemic activity, hepatocellular protective role and restore the histology of the liver and pancreas.
UNASSIGNED: GC tablets could be a promising alternative formulation to control the high blood glucose level in diabetic rats rather than chemically derivatized drugs.
UNASSIGNED: The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin rats\' model in comparison with positive control metformin.
UNASSIGNED: Micrometrics of GC grounded seeds with different excipients were investigated. Then, GC tablets were prepared via direct compression technique. GC tablets were characterized for their uniformity of dosage unit, friability, hardness, disintegration time, and in vitro release. The antidiabetic effect was studied in rats for a period of 28 days. Glycosylated hemoglobin, liver performance, and lipid levels include total cholesterol (TC), triglycerides (TGs), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also estimated. In addition, histopathological study of liver and pancreas was also performed.
UNASSIGNED: Prosolv®EasyTab produced tablets with higher hardness, lower disintegration time, and fast release. GC tablets significantly lower the elevated blood glucose level. In addition, they have antihyperlipidemic activity, hepatocellular protective role and restore the histology of the liver and pancreas.
UNASSIGNED: GC tablets could be a promising alternative formulation to control the high blood glucose level in diabetic rats rather than chemically derivatized drugs.
摘要：
■四叶草，花园水芹(GC),种子有很多天然分子，对不同的疾病有明显的活性。据报道,GC种子具有降低血糖水平的能力。
■这项工作的目的是将GC种子配制成含有固定剂量的研磨种子的口服片剂。此外，在链脲佐菌素大鼠模型中研究了所制备片剂的抗糖尿病性能，并与阳性对照二甲双胍进行了比较。
■研究了具有不同赋形剂的GC研磨种子的微度量。然后，通过直接压片技术制备GC片剂。GC片剂的特征在于其剂量单位的均匀性，脆性,硬度,崩解时间和体外释放。在大鼠中研究了28天的抗糖尿病作用。糖化血红蛋白,肝脏表现，和脂质水平包括总胆固醇（TC），甘油三酯（TG），高密度脂蛋白（HDL），还估计了低密度脂蛋白（LDL）。此外,还进行了肝脏和胰腺的组织病理学研究。
■Prosolv®Easytab生产的片剂硬度更高，更低的崩解时间和快速释放。GC片剂显著降低升高的血糖水平。此外,它们具有抗高脂血症活性，肝细胞保护作用和恢复肝脏和胰腺的组织学。
■GC片剂可能是控制糖尿病大鼠高血糖水平的有前途的替代制剂，而不是化学衍生的药物。
■这项工作的目的是将GC种子配制成含有固定剂量的研磨种子的口服片剂。此外，在链脲佐菌素大鼠模型中研究了所制备片剂的抗糖尿病性能，并与阳性对照二甲双胍进行了比较。
■研究了具有不同赋形剂的GC研磨种子的微度量。然后，通过直接压片技术制备GC片剂。GC片剂的特征在于其剂量单位的均匀性，脆性,硬度,崩解时间和体外释放。在大鼠中研究了28天的抗糖尿病作用。糖化血红蛋白,肝脏表现，和脂质水平包括总胆固醇（TC），甘油三酯（TG），高密度脂蛋白（HDL），还估计了低密度脂蛋白（LDL）。此外,还进行了肝脏和胰腺的组织病理学研究。
■Prosolv®Easytab生产的片剂硬度更高，更低的崩解时间和快速释放。GC片剂显著降低升高的血糖水平。此外,它们具有抗高脂血症活性，肝细胞保护作用和恢复肝脏和胰腺的组织学。
■GC片剂可能是控制糖尿病大鼠高血糖水平的有前途的替代制剂，而不是化学衍生的药物。
