Abstract：
Based primarily on evidence from rodent models fasting is currently believed to improve metabolic health via activation of the AMPK-PGC-1α axis in skeletal muscle. However, it is unclear whether the skeletal muscle AMPK-PGC-1α axis is activated by fasting in humans. The current systematic review examined the fasting response in skeletal muscle from 34 selected studies (7 human, 21 mouse, and 6 rat). From these studies, we gathered 38 unique data points related to AMPK and 47 related to PGC-1α. In human studies, fasting mediated activation of the AMPK-PGC-1α axis is largely absent. Although evidence does support fasting-induced activation of the AMPK-PGC-1α axis in rodent skeletal muscle, the evidence is less robust than anticipated. Our findings question the ability of fasting to activate the AMPK-PGC-1α axis in human skeletal muscle and suggest that the metabolic benefits of fasting in humans are associated with caloric restriction rather than the induction of mitochondrial biogenesis. Registration: https://doi.org/10.17605/OSF.IO/KWNQY.
摘要：
主要基于来自啮齿动物模型的证据,目前认为禁食通过激活骨骼肌中的AMPK-PGC-1α轴改善代谢健康。然而,目前尚不清楚骨骼肌AMPK-PGC-1α轴是否被禁食激活。当前的系统评价检查了34项选定研究中骨骼肌的禁食反应(7人，21只老鼠,和6只老鼠）。从这些研究中,我们收集了38个与AMPK相关的独特数据点和47个与PGC-1α相关的独特数据点。在人类研究中,AMPK-PGC-1α轴的空腹介导激活基本上不存在。尽管有证据支持空腹诱导的啮齿动物骨骼肌AMPK-PGC-1α轴的激活，证据没有预期的那么有力。我们的发现质疑禁食激活人骨骼肌中AMPK-PGC-1α轴的能力，并表明人类禁食的代谢益处与热量限制有关，而不是线粒体生物发生的诱导。注册：https://doi.org/10.17605/OSF。IO/KWNQY。
