PDF(Pubmed)
Abstract：
Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic to humans and are formed by incomplete combustion. PAHs are always present during firefighting operations, and fire department members can be exposed to them in the workplace.
In this study, we analyzed 1-hydroxypyrene (1-OHP) in 36 urine samples from nine firefighters, collected before and after fire training sessions, and 32 urine samples from eight employees at respiratory protection and hose workshops. To assess breakthrough PAH exposure through personal protective equipment and potential dermal uptake, some of the workshop employees wore cotton garments under their regular workwear. Cotton samples were then examined for the presence of 17 semi-volatile and low-volatility PAHs.
After firefighting exercises, we observed approximately a fivefold increase in mean 1-OHP concentrations in samples from firefighters, from 0.24 μg/L to 1.17 μg/L (maximum: 5.31 μg/L). In contrast, 1-OHP levels in workshop employees were found to be low, with the majority of urine samples yielding concentrations below the limit of quantification (LOQ: 0.05 μg/L, maximum: 0.11 μg/L). Similarly, low PAH levels were found on the workshop employees\' cotton undergarments, with maximum concentrations of 250 and 205 ng/g for pyrene and benzo[a]pyrene, respectively.
In conclusion, significant increases in 1-OHP in urine were observed in firefighters after training sessions, whereas work-related exposure remained low among workshop employees.
In this study, we analyzed 1-hydroxypyrene (1-OHP) in 36 urine samples from nine firefighters, collected before and after fire training sessions, and 32 urine samples from eight employees at respiratory protection and hose workshops. To assess breakthrough PAH exposure through personal protective equipment and potential dermal uptake, some of the workshop employees wore cotton garments under their regular workwear. Cotton samples were then examined for the presence of 17 semi-volatile and low-volatility PAHs.
After firefighting exercises, we observed approximately a fivefold increase in mean 1-OHP concentrations in samples from firefighters, from 0.24 μg/L to 1.17 μg/L (maximum: 5.31 μg/L). In contrast, 1-OHP levels in workshop employees were found to be low, with the majority of urine samples yielding concentrations below the limit of quantification (LOQ: 0.05 μg/L, maximum: 0.11 μg/L). Similarly, low PAH levels were found on the workshop employees\' cotton undergarments, with maximum concentrations of 250 and 205 ng/g for pyrene and benzo[a]pyrene, respectively.
In conclusion, significant increases in 1-OHP in urine were observed in firefighters after training sessions, whereas work-related exposure remained low among workshop employees.
摘要：
■多环芳烃（PAHs）对人类具有致癌性，是由不完全燃烧形成的。PAHs在消防行动中始终存在，消防部门成员可以在工作场所接触他们。
■在这项研究中，我们分析了来自9名消防员的36个尿液样本中的1-羟基芘（1-OHP），在消防培训课程之前和之后收集，以及呼吸防护和软管车间八名员工的32份尿液样本。通过个人防护设备和潜在的皮肤吸收来评估突破性的PAH暴露，一些车间员工在常规工作服下穿着棉质服装。然后检查棉花样品中17种半挥发性和低挥发性PAHs的存在。
■消防演习后，我们观察到消防员样本中的平均1-OHP浓度增加了大约五倍，从0.24μg/L到1.17μg/L（最大值：5.31μg/L）。相比之下,车间员工的1-OHP水平较低，大多数尿液样品的浓度低于定量限（LOQ：0.05μg/L，最大值：0.11μg/L）。同样，车间员工的棉质内衣上发现了低PAH水平，芘和苯并[a]芘的最大浓度为250和205ng/g，分别。
■总而言之，训练结束后，消防员观察到尿液中的1-OHP显着增加，而车间员工与工作相关的暴露仍然很低。
■在这项研究中，我们分析了来自9名消防员的36个尿液样本中的1-羟基芘（1-OHP），在消防培训课程之前和之后收集，以及呼吸防护和软管车间八名员工的32份尿液样本。通过个人防护设备和潜在的皮肤吸收来评估突破性的PAH暴露，一些车间员工在常规工作服下穿着棉质服装。然后检查棉花样品中17种半挥发性和低挥发性PAHs的存在。
■消防演习后，我们观察到消防员样本中的平均1-OHP浓度增加了大约五倍，从0.24μg/L到1.17μg/L（最大值：5.31μg/L）。相比之下,车间员工的1-OHP水平较低，大多数尿液样品的浓度低于定量限（LOQ：0.05μg/L，最大值：0.11μg/L）。同样，车间员工的棉质内衣上发现了低PAH水平，芘和苯并[a]芘的最大浓度为250和205ng/g，分别。
■总而言之，训练结束后，消防员观察到尿液中的1-OHP显着增加，而车间员工与工作相关的暴露仍然很低。
