Abstract：
OBJECTIVE: This study evaluated vocal fold leukoplakia using i-scan combined with laryngovideostroboscopy for risk assessment prediction.
METHODS: A total of 141 patients with 218 lesions were enrolled in this study. Morphological characteristics of leukoplakia, assessment of the vascular pattern using i-scan, and vocal fold vibratory function were analyzed.
RESULTS: The number of patients with no, mild, moderate, severe dysplasia, and invasive carcinoma were 68, 40, 17, 46 and 47, respectively. The sensitivity of morphological characteristic, vascular pattern, vibratory function and predictive model were 77.4%, 72%, 69.9%, and 82.8%, respectively. Receiver operating characteristic curve analysis of morphological characteristic, vascular pattern, vibratory function and predictive model were 0.771, 0.824, 0.769, and 0.923, respectively. The results of logistic regression analysis showed that rough morphological types, perpendicular vascular pattern, severe decrease and absence of mucosal waves increased the risk of malignancy (OR = 5.531, 4.973, and 16.992, respectively; P < 0.001).
CONCLUSIONS: I-scan combined with laryngovideostroboscopy can improve the differential diagnosis of low-risk and high-risk vocal fold leukoplakia.
METHODS: A total of 141 patients with 218 lesions were enrolled in this study. Morphological characteristics of leukoplakia, assessment of the vascular pattern using i-scan, and vocal fold vibratory function were analyzed.
RESULTS: The number of patients with no, mild, moderate, severe dysplasia, and invasive carcinoma were 68, 40, 17, 46 and 47, respectively. The sensitivity of morphological characteristic, vascular pattern, vibratory function and predictive model were 77.4%, 72%, 69.9%, and 82.8%, respectively. Receiver operating characteristic curve analysis of morphological characteristic, vascular pattern, vibratory function and predictive model were 0.771, 0.824, 0.769, and 0.923, respectively. The results of logistic regression analysis showed that rough morphological types, perpendicular vascular pattern, severe decrease and absence of mucosal waves increased the risk of malignancy (OR = 5.531, 4.973, and 16.992, respectively; P < 0.001).
CONCLUSIONS: I-scan combined with laryngovideostroboscopy can improve the differential diagnosis of low-risk and high-risk vocal fold leukoplakia.
摘要：
目的：本研究使用i-scan联合喉镜镜检查评估了声带白斑的风险预测。
方法：本研究共纳入141例患者，218个病灶。白斑的形态特征,使用i-scan评估血管模式，并对声带振动功能进行了分析。
结果：没有，温和,中度,严重的发育不良,浸润癌分别为68、40、17、46和47。形态特征的敏感性,血管模式,振动函数和预测模型为77.4%，72%,69.9%,和82.8%，分别。形态特征接收机工作特性曲线分析,血管模式,振动函数和预测模型分别为0.771、0.824、0.769和0.923。Logistic回归分析结果表明,粗糙形态类型,垂直血管模式，粘膜波的严重减少和缺失增加了恶性肿瘤的风险(OR分别=5.531,4.973和16.992;P<0.001).
结论：I-scan联合喉镜检查可提高低危和高危声带白斑的鉴别诊断。
方法：本研究共纳入141例患者，218个病灶。白斑的形态特征,使用i-scan评估血管模式，并对声带振动功能进行了分析。
结果：没有，温和,中度,严重的发育不良,浸润癌分别为68、40、17、46和47。形态特征的敏感性,血管模式,振动函数和预测模型为77.4%，72%,69.9%,和82.8%，分别。形态特征接收机工作特性曲线分析,血管模式,振动函数和预测模型分别为0.771、0.824、0.769和0.923。Logistic回归分析结果表明,粗糙形态类型,垂直血管模式，粘膜波的严重减少和缺失增加了恶性肿瘤的风险(OR分别=5.531,4.973和16.992;P<0.001).
结论：I-scan联合喉镜检查可提高低危和高危声带白斑的鉴别诊断。
