Abstract：
Morning dry mouth (MDM) is a common symptom of Obstructive Sleep Apnea (OSA) yet current OSA screening tools overlook it.
To enhance the specificity of the Stop-Bang questionnaire (SBQ) by adding an MDM symptom.
A retrospective analysis on 590 patients from Peking University First Hospital (2013-2018) suspected of OSA was conducted. They underwent polysomnography. The research incorporated the MDM symptom into SBQ and adjusted the body mass index (BMI) threshold to 28 kg/m2. Predictive parameters were then calculated.
83.1% patients were diagnosed with OSA, with 61.4% reporting MDM. Multivariate regression confirmed MDM significantly influenced Apnea-Hypopnea Index (AHI). Adjusted SBQ with MDM showed a slight decrease in sensitivity but improved specificity, especially when using a BMI threshold of > 28 kg/m2. For AHI ≥ 5 events/h and AHI ≥ 15 events/h, adjusted SBQ with MDM (BMI >28 kg/m2) obtained the highest Youden index.
Incorporating the MDM symptom into SBQ and adjusting the BMI threshold enhances the diagnostic specificity for OSA.
To enhance the specificity of the Stop-Bang questionnaire (SBQ) by adding an MDM symptom.
A retrospective analysis on 590 patients from Peking University First Hospital (2013-2018) suspected of OSA was conducted. They underwent polysomnography. The research incorporated the MDM symptom into SBQ and adjusted the body mass index (BMI) threshold to 28 kg/m2. Predictive parameters were then calculated.
83.1% patients were diagnosed with OSA, with 61.4% reporting MDM. Multivariate regression confirmed MDM significantly influenced Apnea-Hypopnea Index (AHI). Adjusted SBQ with MDM showed a slight decrease in sensitivity but improved specificity, especially when using a BMI threshold of > 28 kg/m2. For AHI ≥ 5 events/h and AHI ≥ 15 events/h, adjusted SBQ with MDM (BMI >28 kg/m2) obtained the highest Youden index.
Incorporating the MDM symptom into SBQ and adjusting the BMI threshold enhances the diagnostic specificity for OSA.
摘要：
■早晨口干（MDM）是阻塞性睡眠呼吸暂停（OSA）的常见症状，但目前的OSA筛查工具却忽略了它。
■通过添加MDM症状来增强Stop-Bang问卷（SBQ）的特异性。
■对2013-2018年北京大学第一医院590例OSA患者进行回顾性分析。他们接受了多导睡眠监测。该研究将MDM症状纳入SBQ，并将体重指数（BMI）阈值调整为28kg/m2。然后计算预测参数。
■83.1%的患者被诊断为OSA,61.4%报告MDM。多因素回归证实MDM显著影响呼吸暂停低通气指数(AHI)。用MDM调整后的SBQ显示灵敏度略有下降，但特异性提高，特别是当使用>28kg/m2的BMI阈值时。对于AHI≥5个事件/h和AHI≥15个事件/h，用MDM调整SBQ(BMI>28kg/m2)获得了最高的Youden指数。
■将MDM症状纳入SBQ并调整BMI阈值可增强OSA的诊断特异性。
■通过添加MDM症状来增强Stop-Bang问卷（SBQ）的特异性。
■对2013-2018年北京大学第一医院590例OSA患者进行回顾性分析。他们接受了多导睡眠监测。该研究将MDM症状纳入SBQ，并将体重指数（BMI）阈值调整为28kg/m2。然后计算预测参数。
■83.1%的患者被诊断为OSA,61.4%报告MDM。多因素回归证实MDM显著影响呼吸暂停低通气指数(AHI)。用MDM调整后的SBQ显示灵敏度略有下降，但特异性提高，特别是当使用>28kg/m2的BMI阈值时。对于AHI≥5个事件/h和AHI≥15个事件/h，用MDM调整SBQ(BMI>28kg/m2)获得了最高的Youden指数。
■将MDM症状纳入SBQ并调整BMI阈值可增强OSA的诊断特异性。
