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Abstract：
A one-pot extraction-assisted d-galactose-to-d-tagatose isomerization strategy was proposed based on the selective extraction of d-tagatose by phenylborate anions. 4-Vinylphenylboronic acid was selected with high extraction efficiency and selectivity towards d-tagatose. The extracted sugars could be desorbed through a two-staged stripping process with the purity of d-tagatose significantly increased. In-situ extraction-assisted d-galactose-to-d-tagatose isomerization was implemented for the first time ever reported, and the effect of boron-to-sugar ratio (boron: sugar) was investigated. The conversion yield of d-tagatose at 60 °C increased from ∼ 39 % (boron: sugar = 0.5) to ∼ 56 % (boron: sugar = 1) but then decreased to ∼ 44 % (boron: sugar = 1.5). With temperature increased to 70 °C, the conversion yield of d-tagatose was further improved to ∼ 61 % (boron: sugar = 1.5), with the minimized formation of byproducts. Moreover, high purity (∼83 %) and concentrated d-tagatose solution (∼40 g/L) was obtained after sequential desorption. The proposed extraction-assisted isomerization strategy achieved improving the yield and purity of d-tagatose, proving its feasibility in industrial applications.
摘要：
基于苯基硼酸根阴离子对d-塔格糖的选择性提取，提出了一锅提取辅助的d-半乳糖至d-塔格糖异构化策略。选择具有高提取效率和对d-塔格糖的选择性的4-乙烯基苯基硼酸。提取的糖可以通过两阶段汽提过程解吸，d-塔格糖的纯度显着增加。首次报道了原位提取辅助的d-半乳糖到d-塔格糖异构化，并研究了硼与糖比（硼：糖）的影响。在60°C时，d-塔格糖的转化率从约39%（硼：糖=0.5）增加到约56%（硼：糖=1），但随后下降到约44%（硼：糖=1.5）。随着温度升高到70°C，d-塔格糖的转化率进一步提高至61%(硼:糖=1.5)，与最小化的副产物的形成。此外，在顺序解吸后获得高纯度(83%)和浓缩的d-塔格糖溶液(40克/升)。提出的萃取辅助异构化策略提高了d-塔格糖的收率和纯度，证明其在工业应用中的可行性。
