PDF(Pubmed)
Abstract：
UNASSIGNED: Alzheimer\'s disease (AD) is a complex neurodegenerative disorder whose etiology involves multiple genetic and environmental factors. Sphingomyelin (SM) is a type of sphingolipid found in cell membranes, and recent evidence suggests a potential link between SM and AD. However, the nature of this relationship remains unclear.
UNASSIGNED: To elucidate the potential causal relationship between SM levels and the risk of developing AD using a two-sample Mendelian randomization approach.
UNASSIGNED: The study utilized data extracted from the genome wide association study database. The primary analysis method was the inverse variance weighted (IVW) method, which was supplemented by weighted median, weighted mode, and MR Egger methods. The study specifically investigated the bidirectional causal relationship between SM and AD, evaluating odds ratios (OR) with a 95% confidence interval (95% CI).
UNASSIGNED: Elevated levels of SM were found to be a risk factor for AD, as shown by IVW(MRE) [OR: 1.001, 95% CI: 1.000 to 1.002; p = 0.020 < 0.05], IVW(FE) [OR: 1.001, 95% CI: 1.001 to 1.002; p = 3.36e-07 < 0.05], and MR Egger. Conversely, AD was demonstrated to lead to an increase in SM levels [IVW(MRE): OR: 5.64e+08, 95% CI: 1.69e+05 to 1.89e+12; p = 1.14e-06 < 0.05], with consistent findings across the IVW(FE), MR Egger, weighted median, and weighted mode methods.
UNASSIGNED: The study establishes a bidirectional positive correlation between SM and AD. Increased SM levels are associated with a higher risk of developing AD, and the presence of AD can further elevate SM levels, potentially exacerbating the disease\'s progression.
UNASSIGNED: To elucidate the potential causal relationship between SM levels and the risk of developing AD using a two-sample Mendelian randomization approach.
UNASSIGNED: The study utilized data extracted from the genome wide association study database. The primary analysis method was the inverse variance weighted (IVW) method, which was supplemented by weighted median, weighted mode, and MR Egger methods. The study specifically investigated the bidirectional causal relationship between SM and AD, evaluating odds ratios (OR) with a 95% confidence interval (95% CI).
UNASSIGNED: Elevated levels of SM were found to be a risk factor for AD, as shown by IVW(MRE) [OR: 1.001, 95% CI: 1.000 to 1.002; p = 0.020 < 0.05], IVW(FE) [OR: 1.001, 95% CI: 1.001 to 1.002; p = 3.36e-07 < 0.05], and MR Egger. Conversely, AD was demonstrated to lead to an increase in SM levels [IVW(MRE): OR: 5.64e+08, 95% CI: 1.69e+05 to 1.89e+12; p = 1.14e-06 < 0.05], with consistent findings across the IVW(FE), MR Egger, weighted median, and weighted mode methods.
UNASSIGNED: The study establishes a bidirectional positive correlation between SM and AD. Increased SM levels are associated with a higher risk of developing AD, and the presence of AD can further elevate SM levels, potentially exacerbating the disease\'s progression.
摘要：
■阿尔茨海默病（AD）是一种复杂的神经退行性疾病，其病因涉及多种遗传和环境因素。神经鞘磷脂（SM）是一种在细胞膜中发现的鞘脂，最近的证据表明SM和AD之间存在潜在的联系。然而,这种关系的性质尚不清楚。
■使用双样本孟德尔随机化方法阐明SM水平与患AD风险之间的潜在因果关系。
■该研究利用了从全基因组关联研究数据库中提取的数据。主要分析方法是逆方差加权(IVW)法，由加权中位数补充，加权模式，和MREgger方法。这项研究特别调查了SM和AD之间的双向因果关系，用95%置信区间(95%CI)评估比值比(OR)。
■发现SM水平升高是AD的危险因素，如IVW（MRE）所示[OR：1.001，95％CI：1.000至1.002；p=0.020<0.05]，IVW（FE）[OR：1.001，95%CI：1.001至1.002；p=3.36e-07<0.05]，还有Egger先生.相反，AD被证明导致SM水平升高[IVW(MRE):OR:5.64e+08,95%CI:1.69e+05至1.89e+12;p=1.14e-06<0.05],与整个IVW(FE)的一致发现，Egger先生,加权中位数，和加权模式方法。
■该研究在SM和AD之间建立了双向正相关。SM水平升高与患AD的风险更高相关，AD的存在可以进一步提高SM水平，可能加剧疾病的进展。
■使用双样本孟德尔随机化方法阐明SM水平与患AD风险之间的潜在因果关系。
■该研究利用了从全基因组关联研究数据库中提取的数据。主要分析方法是逆方差加权(IVW)法，由加权中位数补充，加权模式，和MREgger方法。这项研究特别调查了SM和AD之间的双向因果关系，用95%置信区间(95%CI)评估比值比(OR)。
■发现SM水平升高是AD的危险因素，如IVW（MRE）所示[OR：1.001，95％CI：1.000至1.002；p=0.020<0.05]，IVW（FE）[OR：1.001，95%CI：1.001至1.002；p=3.36e-07<0.05]，还有Egger先生.相反，AD被证明导致SM水平升高[IVW(MRE):OR:5.64e+08,95%CI:1.69e+05至1.89e+12;p=1.14e-06<0.05],与整个IVW(FE)的一致发现，Egger先生,加权中位数，和加权模式方法。
■该研究在SM和AD之间建立了双向正相关。SM水平升高与患AD的风险更高相关，AD的存在可以进一步提高SM水平，可能加剧疾病的进展。
