METHODS: This analysis included 257 adolescents (mean age 14.9 ± 1.14 years; 49.8 % female) with baseline hemoglobin A1c (HbA1c) between 8 and 13 % (64 mmol/mol-119 mmol/mol) from a randomized trial designed to improve glycemia. Eating behaviors and eBFP were determined from surveys and validated equations respectively. Linear mixed models were used to estimate associations. Effect modification was assessed via stratified plots, stratified associations, and interaction terms.
RESULTS: Disordered eating, dietary restraint, and eBFP were significantly higher among females while external eating was higher among males. Disordered eating (β: 0.49, 95 %CI: 0.24, 0.73, p = 0.0001) and restraint (β: 1.11, 95 %CI: 0.29, 1.92, p = 0.0081) were positively associated with eBFP while external eating was not (β: -0.19, 95 %CI: -0.470, 0.096, p = 0.20). Interactions with sex were not significant (p-value range: 0.28-0.64).
CONCLUSIONS: Disordered eating and dietary restraint were positively associated with eBFP, highlighting the potential salience of these eating behaviors to cardiometabolic risk for both female and male adolescents. Prospective studies should investigate whether these eating behaviors predict eBFP longitudinally to inform obesity prevention strategies in T1D.
方法:这项分析包括257名青少年(平均年龄14.9±1.14岁;49.8%为女性),基线血红蛋白A1c(HbA1c)在8-13%(64mmol/mol-119mmol/mol)之间,来自一项旨在改善血糖的随机试验。饮食行为和eBFP分别从调查和验证方程中确定。线性混合模型用于估计关联。通过分层图评估效果变化,分层关联,和互动术语。
结果:饮食失调,饮食限制,女性和eBFP明显较高,而男性外部饮食较高。饮食紊乱(β:0.49,95CI:0.24,0.73,p=0.0001)和克制(β:1.11,95CI:0.29,1.92,p=0.0081)与eBFP呈正相关,而外部饮食则没有(β:-0.19,95CI:-0.470,0.096,p=0.20)。与性别的相互作用不显著(p值范围:0.28-0.64)。
结论:饮食失调与eBFP呈正相关,强调这些饮食行为对女性和男性青少年心脏代谢风险的潜在显著性。前瞻性研究应调查这些饮食行为是否纵向预测eBFP,以告知T1D中的肥胖预防策略。