A total of 37 patients with pathologically proven HEHE, 37 HCC cases, 37 ICC cases, and 37 HMT cases were enrolled from single hospital. The clinical characteristics and ultrasonic features of all cases were summarized and statistically analyzed.
There were significant differences in sex and age between the HEHE group and other three groups (P < 0.001). The probability of HEHE infection with hepatitis B virus was lower than that of HCC and ICC groups (P < 0.05). The probability of elevated serum tumor markers in HEHE was significantly lower than that in the other three groups (P < 0.05). On conventional ultrasound (CUS), the probability of multiple lesions in HEHE was significantly higher than that in the other three groups (P < 0.05). On contrast-enhanced ultrasound (CEUS), the time to wash out in HEHE was significantly shorter than that of the other three groups (P < 0.001). The proportion of synchronous or slow enhancement in HEHE was significantly higher than that of the other three groups (P < 0.001). The proportion of HEHE with iso- or hypo-enhancement was significantly higher than in HCC and HMT groups (P < 0.05).
HEHE mainly performed multiple hypoechoic lesions on CUS and displayed greater odds of synchronous enhancement in arterial phase, iso- or hypo-enhancement in peak time and wash out more quickly on CEUS, which allowed for differentiation from other common malignant tumors.
方法:共37例经病理证实的HEHE患者,37例HCC,37起国际刑事法院案件,37例HMT患者来自单一医院。对所有病例的临床特征和超声特征进行总结和统计学分析。
结果:HEHE组与其他三组在性别、年龄方面差异有统计学意义(P<0.001)。HEHE感染乙型肝炎病毒的概率低于HCC组和ICC组(P<0.05)。HEHE组血清肿瘤标志物升高的概率明显低于其他3组(P<0.05)。在常规超声(CUS)上,HEHE中多发病变的概率明显高于其他三组(P<0.05)。在超声造影(CEUS)上,HEHE冲洗时间明显短于其他三组(P<0.001)。HEHE同步或缓慢增强的比例明显高于其他三组(P<0.001)。HEHE等增强或低增强的比例明显高于HCC和HMT组(P<0.05)。
结论:HEHE主要表现为CUS多发低回声病变,动脉期同步增强的几率较大,峰值时间的等值增强或低增强,并且在CEUS上洗得更快,这允许与其他常见的恶性肿瘤区分开来。