Abstract：
A remarkable challenge in the anticancer drug delivery system is developing an implantable system that can improve the chemotherapeutic effect. Polyurethane is an excellent implantable substrate, with flaws in hydrophobicity. We modified polyurethane via the chemical aminolysis technique to enhance the wettability and protein interaction. The created pores can release the rutin complex incorporated in the polyurethane matrix. In this work, the hybrid polymer matrix consists of Mxene synthesized via a sustainable and simple method by introducing a toxic-free MAX phase and etchants. The incorporation of Mxene and PCL can enhance physicochemical and biological compatibility. Sustainable Mxene increases oxidative stress, cell death, and antibacterial activity, which also resulted in the Mxene@APU/PCL film. Meanwhile, the drug release with respect to pH sensitivity was demonstrated in which Mxene and Mxene@APU/PCL films showed the highest release at pH 5.2; this indicates that the prepared Mxene and aminolyzed polyurethane can function according to the biological system and release the drug from the polymer matrix on slow degradation and swellability. The Mxene and Mxene@APU/PCL films showed 93.2% drug release with oxidative stress on THP-1 cells, which causes rupturing and apoptosis of cancerous cells. The Mxene@APU/PCL film can show great potential in future implantable anticancer drug delivery systems.
摘要：
抗癌药物递送系统中的一个显著挑战是开发可改善化疗效果的可植入系统。聚氨酯是一种优良的可植入基材，具有疏水性缺陷。我们通过化学氨解技术对聚氨酯进行改性，以增强润湿性和蛋白质相互作用。产生的孔可以释放掺入聚氨酯基质中的芦丁复合物。在这项工作中,混合聚合物基质由Mxene组成，该Mxene通过引入无毒的MAX相和蚀刻剂通过可持续且简单的方法合成。Mxene和PCL的掺入可以增强物理化学和生物相容性。可持续Mxene增加氧化应激，细胞死亡,和抗菌活性，这也导致了Mxene@APU/PCL薄膜。同时,在pH敏感性方面的药物释放被证明，其中Mxene和Mxene@APU/PCL膜在pH5.2时显示出最高的释放；这表明制备的Mxene和氨基分解聚氨酯可以根据生物系统起作用，并在缓慢降解和溶胀性下从聚合物基质中释放药物。Mxene和Mxene@APU/PCL膜对THP-1细胞显示出93.2％的药物释放与氧化应激，导致癌细胞破裂和凋亡。Mxene@APU/PCL膜可以在未来的可植入抗癌药物递送系统中显示出巨大的潜力。
