Abstract：
This study aimed to analyze research projects on lung transplant funded by the National Natural Science Foundation of China from 1986 to 2022 and to provide a scientific reference for lung transplant research.
We identified research hotspots and frontiers in the field of lung transplant research using CiteSpace visualization.
From 1986 to 2022, the National Natural Science Foundation of China funded 93 projects related to lung transplant, with an average of 2.51 projects and ¥0.94 million annually. The National Natural Science Foundation of China funded 30 institutions across 20 provinces, with general and youth science foundation projects comprising 45.16% and 41.93% of the total projects, respectively. The main categories of disciplines included H0113 respiratory intervention, tracheal reconstruction, and lung transplantation; H1105 organ transplantation and transplant immunization; and H0109 acute lung injury and acute respiratory distress syndrome. The research hotspots mainly included ischemia-reperfusion injury, gene regulation, obliterative bronchiolitis, rejection reaction, T cells, and stem cells. The 6 main research clusters were ischemia-reperfusion injury, immune tolerance, obliterative bronchiolitis, stem cells, pulmonary fibrosis, and rejection reaction. The main key word bursts in the past 5 years were \"vein endothelial\" and \"ex vivo lung perfusion.\"
In the past 37 years, National Natural Science Foundation of China-funded projects have significantly advanced the clinical application and basic research of lung transplantation. However, compared with developed countries and other solidorgan transplantations, several problems still require attention and improvements in lung transplant research in China.
We identified research hotspots and frontiers in the field of lung transplant research using CiteSpace visualization.
From 1986 to 2022, the National Natural Science Foundation of China funded 93 projects related to lung transplant, with an average of 2.51 projects and ¥0.94 million annually. The National Natural Science Foundation of China funded 30 institutions across 20 provinces, with general and youth science foundation projects comprising 45.16% and 41.93% of the total projects, respectively. The main categories of disciplines included H0113 respiratory intervention, tracheal reconstruction, and lung transplantation; H1105 organ transplantation and transplant immunization; and H0109 acute lung injury and acute respiratory distress syndrome. The research hotspots mainly included ischemia-reperfusion injury, gene regulation, obliterative bronchiolitis, rejection reaction, T cells, and stem cells. The 6 main research clusters were ischemia-reperfusion injury, immune tolerance, obliterative bronchiolitis, stem cells, pulmonary fibrosis, and rejection reaction. The main key word bursts in the past 5 years were \"vein endothelial\" and \"ex vivo lung perfusion.\"
In the past 37 years, National Natural Science Foundation of China-funded projects have significantly advanced the clinical application and basic research of lung transplantation. However, compared with developed countries and other solidorgan transplantations, several problems still require attention and improvements in lung transplant research in China.
摘要：
目的：本研究旨在分析1986-2022年国家自然科学基金资助的肺移植研究项目，为肺移植研究提供科学依据。
方法：我们使用CiteSpace可视化确定了肺移植研究领域的研究热点和前沿。
结果：从1986年到2022年，国家自然科学基金资助了93个与肺移植有关的项目，平均2.51个项目，每年94万日元。国家自然科学基金委员会资助了20个省的30个机构，普通和青年科学基金项目占总项目的45.16%和41.93%，分别。学科的主要类别包括H0113呼吸干预，气管重建,和肺移植；S1105器官移植和移植免疫；和H0109急性肺损伤和急性呼吸窘迫综合征。研究热点主要包括缺血再灌注损伤,基因调控，闭塞性细支气管炎,排斥反应，T细胞,和干细胞。6个主要研究集群是缺血再灌注损伤，免疫耐受，闭塞性细支气管炎,干细胞,肺纤维化，和排斥反应。过去5年的主要关键词是“静脉内皮”和“离体肺灌注”。\"
结论：在过去的37年中，国家自然科学基金资助项目对肺移植的临床应用和基础研究有了显著的推进。然而,与发达国家和其他固体器官移植相比，我国肺移植研究中还存在一些问题需要注意和改进。
方法：我们使用CiteSpace可视化确定了肺移植研究领域的研究热点和前沿。
结果：从1986年到2022年，国家自然科学基金资助了93个与肺移植有关的项目，平均2.51个项目，每年94万日元。国家自然科学基金委员会资助了20个省的30个机构，普通和青年科学基金项目占总项目的45.16%和41.93%，分别。学科的主要类别包括H0113呼吸干预，气管重建,和肺移植；S1105器官移植和移植免疫；和H0109急性肺损伤和急性呼吸窘迫综合征。研究热点主要包括缺血再灌注损伤,基因调控，闭塞性细支气管炎,排斥反应，T细胞,和干细胞。6个主要研究集群是缺血再灌注损伤，免疫耐受，闭塞性细支气管炎,干细胞,肺纤维化，和排斥反应。过去5年的主要关键词是“静脉内皮”和“离体肺灌注”。\"
结论：在过去的37年中，国家自然科学基金资助项目对肺移植的临床应用和基础研究有了显著的推进。然而,与发达国家和其他固体器官移植相比，我国肺移植研究中还存在一些问题需要注意和改进。
