PDF(Pubmed)
Abstract：
Knowledge of a valid, well-designed, and targeted theory-based framework helps better characterize reasons for HPV vaccine hesitancy and identify promising approaches to increase vaccination rates for eligible individuals. This study evaluated health theories in explaining factors affecting HPV vaccination and used a theoretical framework to identify direct and indirect predictors and mediators of HPV vaccination. A cross-sectional survey regarding HPV vaccine uptake and related factors was conducted among 1306 teenagers and young adults in the Midwest, US, in March and April 2023. Structural equation modeling confirmed fit of the framework based on the Integrated Health Theory (IHT) to the HPV vaccine data (Comparative Fit Index = 0.93; Tucker-Lewis Index = 0.92; Root Mean Square Error of Approximation = 0.053). While willingness to uptake the HPV vaccine directly predicted increased uptake (p < 0.001), perceived benefits (p < 0.001) and barriers (p < 0.023) about the vaccine indirectly predicted increased and decreased uptake, respectively. In turn, beliefs about susceptibility (p = 0.005) and severity (p < 0.001) of HPV infection and associated cancers and barriers to vaccination in general (p < 0.001) indirectly predicted willingness to uptake the vaccine. In conclusion, IHT can be appropriate in examining predictors of HPV vaccine uptake in teenagers and young adults in the US, particularly in the Midwest.
摘要：
有效的知识，精心设计,和有针对性的基于理论的框架有助于更好地描述HPV疫苗犹豫的原因,并确定有希望的方法来提高符合条件的个体的疫苗接种率.这项研究评估了解释影响HPV疫苗接种的因素的健康理论，并使用理论框架来确定HPV疫苗接种的直接和间接预测因子和介体。在中西部1306名青少年和年轻人中进行了关于HPV疫苗摄取和相关因素的横断面调查。US,2023年3月和4月。结构方程模型证实了基于综合健康理论(IHT)的框架与HPV疫苗数据的拟合(比较拟合指数=0.93;塔克-刘易斯指数=0.92;近似均方根误差=0.053)。虽然摄入HPV疫苗的意愿直接预测了摄入的增加（p<0.001），关于疫苗的感知益处(p<0.001)和障碍(p<0.023)间接预测了摄取的增加和减少，分别。反过来,关于HPV感染和相关癌症的易感性(p=0.005)和严重程度(p<0.001)以及一般疫苗接种障碍(p<0.001)的信念间接预测了接种疫苗的意愿.总之,IHT可适用于检查美国青少年和年轻人HPV疫苗摄取的预测因子，尤其是在中西部。
