PDF(Pubmed)
Abstract：
In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms.
摘要：
在这次审查中,对干粉吸入器(DPI)进行了广泛的分析，着眼于他们的特点，配方，稳定性,和制造业。研究了肺部分娩的优势，以及粒径在药物沉积中的意义。还对DPI配方的制备进行了全面探索,包括粉末的物理化学表征，粉末加工技术，和制定方面的考虑。除了制造程序，还讨论了测试方法，提供对DPI配方的开发和评估的见解。这篇综述还探讨了特定于DPI的设计基础和关键属性，强调其优化对实现有效吸入治疗的意义。此外,3个DPI胶囊的形态和稳定性(Spiriva，Braltus,和Onbrez)进行了调查，为这些配方的特性提供有价值的见解。总之,这些发现有助于更深入地理解DPI及其发展，性能，并优化吸入剂型。
