PDF(Pubmed)
Abstract：
Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [Mo12O28(μ-L)8]4- (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [Mo2O4(C2O4)2(H2O)2]2- in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.
摘要：
在经过充分研究和积极发展的化合物是多金属氧酸盐（POM），显示在许多领域的应用。扩展这类化合物，我们引入了新的多金属氧簇（POMCs）[Mo12O28（μ-L）8]4-（L=吡唑（pz）或三唑（1,2,3-trz或1,2,4-trz）亚类，在结构上类似于POM，但包含通过桥接氧代和有机配体连接的双核Mo2O4簇。在有机配体熔体中，由双核簇[Mo2O4（C2O4）2（H2O）2]2-通过安瓿合成获得的络合物在水溶液中可溶且稳定。除了在固态和水溶液中的详细表征外，研究了化合物对正常细胞和癌细胞的生物学特性，并且证明了针对甲型流感病毒（H5N1亚型）的抗病毒活性。
