{Reference Type}: Journal Article
{Title}: Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity.
{Author}: Konkova AV;Savina IV;Evtushok DV;Pozmogova TN;Solomatina MV;Nokhova AR;Alekseev AY;Kuratieva NV;Eltsov IV;Yanshole VV;Shestopalov AM;Ivanov AA;Shestopalov MA;
{Journal}: Molecules
{Volume}: 28
{Issue}: 24
{Year}: 2023 Dec 14
{Factor}: 4.927
{DOI}: 10.3390/molecules28248079
{Abstract}: Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [Mo12O28(μ-L)8]4- (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [Mo2O4(C2O4)2(H2O)2]2- in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.