PDF(Pubmed)
Abstract：
Curcumin is a natural polyphenol derived from turmeric (Curcuma longa) root that has been used for centuries as a spice, coloring agent, and medicine. Curcumin presents anti-inflammatory, antioxidant, anticarcinogenic, antimicrobial, antiviral, antimalarial, hepatoprotective, thrombosuppressive, cardiovascular, hypoglycemic, antiarthritic, and anti-neurodegenerative properties. It scavenges different forms of free radicals and acts on transcription factors, growth factors and their receptors, cytokines, enzymes, and genes, regulating cell proliferation and apoptosis. Curcumin is electroactive, and a relationship between its electron transfer properties and radical-scavenging activity has been highlighted. The objective of this review is to provide a comprehensive overview of the curcumin electron transfer reactions, with emphasis on the controversial aspects related to its oxidation mechanism. The final sections will focus on the electroanalysis of curcumin in natural products, highlighting the most important sensing strategies, based on functional electrodes and nanostructured materials, essential for the development of more efficient in vitro methods of detection and quantification of curcumin in food samples, supplements, and nutripharmaceuticals.
摘要：
姜黄素是一种天然多酚，来自姜黄（姜黄）根，已被用作香料几个世纪，着色剂，和医学。姜黄素具有抗炎作用，抗氧化剂，抗癌，抗菌，抗病毒，抗疟药,保肝,血栓抑制,心血管,低血糖,抗关节炎,和抗神经退行性特性。它清除不同形式的自由基并作用于转录因子，生长因子及其受体，细胞因子,酶，和基因，调节细胞增殖和凋亡。姜黄素具有电活性,并强调了其电子转移性质与自由基清除活性之间的关系。这篇综述的目的是提供姜黄素电子转移反应的全面概述，重点是与其氧化机理相关的有争议的方面。最后一部分将集中在天然产物中姜黄素的电分析，强调最重要的传感策略，基于功能电极和纳米结构材料，对于开发更有效的体外检测和定量食品样品中姜黄素的方法至关重要，补充剂,和营养药物。
