METHODS: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.
RESULTS: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).
CONCLUSIONS: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.
方法:在一项人群研究中检测到有VDD(25OHD<25nmol/L)的健康婴儿,收集他们的人口统计学和临床数据。
结果:纳入了131名受试者(男孩=66%)。他们的第一个血清25OHD是在中位年龄87.5天服用的。没有人接受高剂量维生素D补充剂治疗,但有些人每天服用400IU的维生素D。在252.5天的中位年龄再次评估它们,当时15个保持VDD,26个处于不足范围(25-49.9nmol/L)。所有持续性VDD儿童均采用纯母乳喂养。纯母乳喂养和不补充维生素D是持续维生素D不足(<50nmol/L)的重要危险因素。
结论:持续VDD在纯母乳喂养和未接受维生素D补充的婴儿中很常见。