PDF(Pubmed)
Abstract：
OBJECTIVE: The usual recommended intake of vitamin D for healthy infants is 400 international unit (IU) daily. However, a high dose of vitamin D at 2000-3000 IU daily is needed for those with vitamin D deficiency (VDD). This study aimed to assess the natural history of a group of healthy infants with VDD and the associated factors for persistent VDD.
METHODS: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.
RESULTS: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).
CONCLUSIONS: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.
METHODS: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.
RESULTS: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).
CONCLUSIONS: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.
摘要：
目的：健康婴儿通常推荐的维生素D摄入量为每天400国际单位（IU）。然而,维生素D缺乏症(VDD)患者需要每日2000-3000IU的高剂量维生素D.这项研究旨在评估一组患有VDD的健康婴儿的自然史以及持续VDD的相关因素。
方法：在一项人群研究中检测到有VDD（25OHD<25nmol/L）的健康婴儿，收集他们的人口统计学和临床数据。
结果：纳入了131名受试者（男孩=66%）。他们的第一个血清25OHD是在中位年龄87.5天服用的。没有人接受高剂量维生素D补充剂治疗，但有些人每天服用400IU的维生素D。在252.5天的中位年龄再次评估它们，当时15个保持VDD，26个处于不足范围（25-49.9nmol/L）。所有持续性VDD儿童均采用纯母乳喂养。纯母乳喂养和不补充维生素D是持续维生素D不足（<50nmol/L）的重要危险因素。
结论：持续VDD在纯母乳喂养和未接受维生素D补充的婴儿中很常见。
方法：在一项人群研究中检测到有VDD（25OHD<25nmol/L）的健康婴儿，收集他们的人口统计学和临床数据。
结果：纳入了131名受试者（男孩=66%）。他们的第一个血清25OHD是在中位年龄87.5天服用的。没有人接受高剂量维生素D补充剂治疗，但有些人每天服用400IU的维生素D。在252.5天的中位年龄再次评估它们，当时15个保持VDD，26个处于不足范围（25-49.9nmol/L）。所有持续性VDD儿童均采用纯母乳喂养。纯母乳喂养和不补充维生素D是持续维生素D不足（<50nmol/L）的重要危险因素。
结论：持续VDD在纯母乳喂养和未接受维生素D补充的婴儿中很常见。
