PDF(Pubmed)
Abstract：
Babesia species infect a very wide range of mammal hosts across the globe, and zoonotic infections are of growing concern. Several species of the Babesia genus infect dogs, and some of these cause significant morbidity and mortality. The Apicomplexan parasite resides within the red cell and infections result in direct damage to the host through intra- and extravascular hemolysis. An exuberant inflammatory response by the host to some species of Babesia parasites also results in significant collateral damage to the host. Canine infections have been the subject of many studies as the well-being of these companion animals is increasingly threatened by the spread of tick vectors and an increasingly mobile dog population. There are currently no widely available and effective vaccines, and effective treatment can be challenging. Understanding disease pathogenesis underlies the development of new treatments. The varying pathogenicity of the various Babesia parasite species that infect dogs offers an opportunity to explore the molecular basis for the wide range of diseases caused by infection with this parasite genus. In this review, we focus on what has been reported about the clinical presentation of Babesia-infected dogs in an attempt to compare the severity of disease caused by different Babesia species.
摘要：
巴贝虫物种感染了全球范围内非常广泛的哺乳动物宿主，和人畜共患感染越来越受到关注。巴贝虫属的几种感染狗，其中一些引起显著的发病率和死亡率。顶孔虫寄生虫驻留在红细胞内，感染通过血管内和血管外溶血导致对宿主的直接损害。宿主对一些巴贝虫寄生虫物种的旺盛的炎症反应也导致对宿主的显著附带损害。犬类感染已成为许多研究的主题，因为这些伴侣动物的健康越来越受到tick媒介的传播和越来越多的流动狗种群的威胁。目前没有广泛可用的有效疫苗，和有效的治疗可能是具有挑战性的。了解疾病的发病机理是开发新的治疗方法的基础。感染狗的各种巴贝斯虫寄生虫物种的不同致病性为探索由这种寄生虫属感染引起的广泛疾病的分子基础提供了机会。在这次审查中,我们关注关于感染巴贝斯虫的犬的临床表现的报道,试图比较由不同巴贝斯虫物种引起的疾病的严重程度.
